Effective synthetic strategy towards highly selective macrocyclic anion receptors based on static combinatorial chemistry
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron"
DOI: 10.1016/j.tet.2020.131693
Abstract: Abstract We present the synthesis, using combinatorial chemistry methodology, of a series of 11 selective anion receptors with special affinity for carboxylates. These compounds contain a urea function and their macrocyclic platform has the structure… read more here.
Keywords: combinatorial chemistry; synthetic strategy; chemistry; effective synthetic ... See more keywords
The development of an effective synthetic route of lesinurad (RDEA594)
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DOI: 10.1186/s13065-017-0316-y
Abstract: BackgroundLesinurad is a novel selective uric acid salt transport protein 1 (URAT1) inhibitor which is approved in the USA for the treatment of gout. However, there are some shortcomings among the reported synthetic routes, such… read more here.
Keywords: development effective; effective synthetic; route lesinurad; synthetic route ... See more keywords