NeuNAc oxime: A slow-binding and effectively irreversible inhibitor of the sialic acid synthase NeuB.
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DOI: 10.1021/acs.biochem.9b00654
Abstract: NeuB is a bacterial sialic acid synthase used by neuroinvasive bacteria to synthesize N-acetylneuraminate (NeuNAc), helping them to evade the host immune system. NeuNAc oxime is a potent slow-binding NeuB inhibitor. It dissociated too slowly… read more here.
Keywords: inhibitor; binding; acid synthase; effectively irreversible ... See more keywords