PKG II effectively reversed EGF‐induced protein expression alterations in human gastric cancer cell lines
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.10912
Abstract: Epidermal growth factor receptor (EGFR) plays an important role in gastric cancer (GC) progression. Our previous data demonstrated that type II cGMP‐dependent protein kinase (PKG II) could block the EGF‐EGFR axis as well as down‐stream… read more here.
Keywords: protein expression; gastric cancer; effectively reversed; pkg ... See more keywords
Conjugates Derived from Lapatinib Derivatives with Cancer Cell Stemness Inhibitors Effectively Reversed Drug Resistance in Triple-Negative Breast Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01013
Abstract: Increasing evidence indicates that the cancer stem cell (CSC) subpopulation contributes to the therapeutic resistance and metastasis of tumors, leading to patient recurrence and death. Herein, we designed and synthesized several compounds by conjugating lapatinib… read more here.
Keywords: negative breast; lapatinib derivatives; effectively reversed; resistance ... See more keywords