A dormant T‐cell population with autoimmune potential exhibits low self‐reactivity and infiltrates islets in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149690
Abstract: The contribution of low‐affinity T cells to autoimmunity in the context of polyclonal T‐cell responses is understudied due to the limitations in their capture by tetrameric reagents and low level of activation in response to… read more here.
Keywords: cell; affinity; reactivity; effector ... See more keywords
The medulla controls effector primed γδT-Cell developmenti in the adult mouse thymus.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202350388
Abstract: γδT cells are produced in the thymus throughout life and provide immunity at epithelial‐rich sites. Unlike conventional αβT cells, γδT‐cell development involves intrathymic acquisition of effector function, with priming for either IL17 or IFN‐γ production… read more here.
Keywords: cell; thymus; ifn; effector ... See more keywords
Leptosphaeria maculans isolates with variations in AvrLm1 and AvrLm4 effector genes induce differences in defence responses but not in resistance phenotypes in cultivars carrying the Rlm7 gene.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7432
Abstract: BACKGROUND The phoma stem canker pathogen Leptosphaeria maculans is one of the most widespread and devastating pathogens of oilseed rape (Brassica napus) in the world. Pathogen colonisation is stopped by an interaction of a pathogen… read more here.
Keywords: rlm7; defence; avrlm1 avrlm4; resistance ... See more keywords
Saprotrophic yeasts formerly classified as Pseudozyma have retained a large effector arsenal, including functional Pep1 orthologs
Sign Up to like & getrecommendations! Published in 2019 at "Mycological Progress"
DOI: 10.1007/s11557-019-01486-2
Abstract: The basidiomycete smut fungi are predominantly plant parasitic, causing severe losses in some crops. Most species feature a saprotrophic haploid yeast stage, and several smut fungi are only known from this stage, with some isolated… read more here.
Keywords: plant; pseudozyma; pep1 orthologs; saprotrophic yeasts ... See more keywords
Learning based end effector tracking control of a mobile manipulator for performing tasks on an uneven terrain
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Intelligent Robotics and Applications"
DOI: 10.1007/s41315-019-00081-8
Abstract: A Mobile manipulator (MM) combines the ability to move on an uneven terrain and perform a desired task using the manipulator arm, like drilling, welding, pick and place, etc. However, due to slip, modeling and… read more here.
Keywords: uneven terrain; kinematics; end effector; mobile manipulator ... See more keywords
Overexpression of early T cell differentiation-specific transcription factors transforms the terminally differentiated effector T cells into less differentiated state.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2020.104118
Abstract: The in vivo proliferation and viability of transfused engineered T cells markedly limits the long-term effect of adoptive cell therapy on tumors. The therapeutic efficacy and proliferative potential of T cells are reported to be… read more here.
Keywords: cell; differentiation specific; specific transcription; differentiation ... See more keywords
T-Bet+ IgM Memory Cells Generate Multi-lineage Effector B Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.06.074
Abstract: SUMMARY Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-… read more here.
Keywords: memory cells; multi lineage; igm memory; bet igm ... See more keywords
Using CRISPR to enhance T cell effector function for therapeutic applications
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cytox.2020.100049
Abstract: T cells are critical to fight pathogenic microbes and combat malignantly transformed cells in the fight against cancer. To exert their effector function, T cells produce effector molecules, such as the pro-inflammatory cytokines IFN-γ, TNF-α… read more here.
Keywords: enhance cell; cell; effector function; effector ... See more keywords
Mycobacterium tuberculosis CRISPR/Cas system Csm1 holds clues to the evolutionary relationship between DNA polymerase and cyclase activity.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.12.014
Abstract: Prokaryotic CRISPR/Cas systems confer immunity against invading nucleic acids through effector complexes. Csm1, the signature protein of Type III effector complexes, catalyses cyclic oligoadenylate synthesis when in the effector complex, but not when alone, activating… read more here.
Keywords: crispr cas; dna polymerase; polymerase; cyclase ... See more keywords
Prediction of effector proteins and their implications in pathogenicity of phytopathogenic filamentous fungi: A review.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.02.133
Abstract: Plant pathogenic fungi encode and secrete effector proteins to promote pathogenesis. In recent years, the important role of effector proteins in fungi and plant host interactions has become increasingly prominent. In this review, the functional… read more here.
Keywords: proteins implications; implications pathogenicity; prediction effector; plant ... See more keywords
Optimal expression of a Fab-effector fusion protein in Escherichia coli by removing the cysteine residues responsible for an interchain disulfide bond of a Fab molecule.
Sign Up to like & getrecommendations! Published in 2017 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.02.008
Abstract: Development of novel bi-functional or even tri-functional Fab-effector fusion proteins would have a great potential in the biomedical sciences. However, the expression of Fab-effector fusion proteins in Escherichia coli is problematic especially when a eukaryotic… read more here.
Keywords: effector fusion; fab; expression; fab effector ... See more keywords