Eomesodermin driven IL-10 production in effector CD8+ T cells promotes a memory phenotype.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.11.008
Abstract: CD8+ T cell differentiation is controlled by the transcription factors T-bet and Eomesodermin, in concert with the cytokines IL-2, IL-10 and IL-12. Among these pathways, the mechanisms by which T-box proteins and IL-10 interact to… read more here.
Keywords: cd8; cd8 cells; effector cd8; memory phenotype ... See more keywords
Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.103932
Abstract: Summary Nicotinamide (NAM) shapes T cell responses but its precise molecular mechanism of action remains elusive. Here, we show that NAM impairs naive T cell effector transition but also effector T cells themselves. Although aerobic… read more here.
Keywords: effector; cell; cell responses; breaks effector ... See more keywords
Determinants of hepatic effector CD8+ T cell dynamics.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2016.07.011
Abstract: Antigen-specific effector CD8+ T cells play a critical role in controlling hepatic infections, such as the one caused by hepatitis B virus (HBV). We review here recent results where we coupled advanced dynamic imaging with… read more here.
Keywords: cell; cd8 cells; effector cd8; determinants hepatic ... See more keywords
Clonally expanded, thyrotoxic effector CD8+ T cells driven by IL-21 contribute to checkpoint inhibitor thyroiditis
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.adg0675
Abstract: Autoimmune toxicity occurs in up to 60% of patients treated with immune checkpoint inhibitor (ICI) therapy for cancer and represents an increasing clinical challenge for expanding the use of these treatments. To date, human immunopathogenic… read more here.
Keywords: effector cd8; thyroiditis; cd8 cells; ici thyroiditis ... See more keywords
Tyrosine kinase inhibition alters intratumoral CD8+ T-cell subtype composition and activity.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-21-1039
Abstract: Targeted therapy with a tyrosine kinase inhibitor (TKI) such as imatinib is effective in treating gastrointestinal stromal tumor (GIST), but it is rarely curative. Despite the presence of a robust immune CD8+ T-cell infiltrate, combining… read more here.
Keywords: cell; cd8 cell; tyrosine kinase; cd8 cells ... See more keywords
Corrigendum: Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01367
Abstract: [This corrects the article DOI: 10.3389/fimmu.2019.02206.]. read more here.
Keywords: defective transcriptional; cd8 cells; effector cd8; programming effector ... See more keywords
Treg and Oligoclonal Expansion of Terminal Effector CD8+ T Cell as Key Players in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.620596
Abstract: The classical paradigm of host-tumor interaction, i.e. elimination, equilibrium, and escape (EEE), is reflected in the clinical behavior of myeloma which progresses from the premalignant condition, Monoclonal Gammopathy of Unknown Significance (MGUS). Despite the role… read more here.
Keywords: cd8; myeloma; terminal effector; effector cd8 ... See more keywords
Firefly luciferase-based chronological measurement of effector CD8+ T-cell activity using a multi-chamber luminometer.
Sign Up to like & getrecommendations! Published in 2023 at "Bioanalysis"
DOI: 10.4155/bio-2022-0208
Abstract: Background: Although cell-mediated cytotoxicity has been evaluated with various protocols, methods for monitoring cytotoxicity in a time series have not been established. This work describes a method for evaluating cytotoxicity using a multi-chamber real-time luminometer.… read more here.
Keywords: cell; using multi; multi chamber; effector cd8 ... See more keywords