A bispecific peptide-polymer conjugate bridging target-effector cells to enhance immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202202977
Abstract: Peptide-based immune checkpoint inhibitors exhibited remarkable therapeutic benefits although their application was hindered by quick blood clearance and low affinity with receptors. The modification of the peptides into artificial antibodies was an ideal platform to… read more here.
Keywords: polymer conjugate; immunotherapy; bispecific peptide; effector cells ... See more keywords
Antigen clearance at the peak of the primary immune response induces experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250122
Abstract: Autoimmune demyelinating diseases can be induced by an immune response against myelin peptides; however, the exact mechanism underlying the development of such diseases remains unclear. In experimental autoimmune encephalomyelitis, we found that the clearance of… read more here.
Keywords: experimental autoimmune; effector cells; antigen; immune response ... See more keywords
Tumor Microenvironment: No Effector T Cells without Dendritic Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.04.007
Abstract: Successful antitumor immunity is thought to require T cell entry into tumors, though mechanisms regulating this process remain unclear. In this issue of Cancer Cell, Spranger et al. indicate that chemokines produced by intratumoral Batf3 dendritic cells… read more here.
Keywords: cell; microenvironment effector; dendritic cells; effector cells ... See more keywords
Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.05.064
Abstract: IL-17-producing γδ T cells express oligoclonal Vγ4+ and Vγ6+ TCRs, mainly develop in the prenatal thymus, and later persist as long-lived self-renewing cells in all kinds of tissues. However, their exchange between tissues and the mechanisms… read more here.
Keywords: single cell; scart1 cells; cells skin; effector cells ... See more keywords
Innate effector cells in angiogenesis and lymphangiogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2018.05.002
Abstract: Angiogenesis and lymphangiogenesis are distinct and complex processes requiring a finely tuned balance between stimulatory and inhibitory signals. During adulthood, angiogenesis and lymphangiogenesis are activated at sites of tumor growth, tissue injury and remodeling, and… read more here.
Keywords: lymphangiogenesis; cells angiogenesis; innate effector; effector cells ... See more keywords
TNF activity and T cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2016.08.003
Abstract: TNF (tumor necrosis factor) is both a pro-inflammatory and anti-inflammatory cytokine that is central to the development of autoimmune disease, cancer, and protection against infectious pathogens. As well as a myriad other activities, TNF can… read more here.
Keywords: cells tnf; effector cells; biology; activity cells ... See more keywords
TLR8 combined withTLR3 or TLR4 agonists enhances DC-NK driven effector Tc1 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.10.015
Abstract: BACKGROUND Most current prophylactic vaccines confer protection primarily through humoral immunity. Indeed, aluminum salts which have been widely used as adjuvants in vaccines primarily enhance Th2-driven antibody responses. Therefore, new vaccines formulation is moving toward… read more here.
Keywords: tlr3 tlr4; tlr agonists; effector cells; tc1 cells ... See more keywords
Retinoic acid takes effector T cells to the gallows: P2X7, the molecular hangman
Sign Up to like & getrecommendations! Published in 2017 at "Mucosal Immunology"
DOI: 10.1038/mi.2016.117
Abstract: Effector T-cell contraction is one of the primary means by which immune homeostasis in the peripheral tissues is reestablished following an inflammatory response. In this issue of Mucosal Immunology, Hashimoto-Hill et al.1 show that retinoic… read more here.
Keywords: acid takes; effector cells; retinoic acid; effector ... See more keywords
Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-020-00575-7
Abstract: Deciphering how T-cell antigen receptor signals are modulated by coinhibitors is a fundamental goal in immunology and of considerable clinical interest because blocking coinhibitory signals via therapeutic antibodies have become a standard cancer immunotherapeutic strategy.… read more here.
Keywords: stimulation; tim3; effector cells; fig ... See more keywords
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1620-6
Abstract: The responses of CD8+ T cells to hepatotropic viruses such as hepatitis B range from dysfunction to differentiation into effector cells, but the mechanisms that underlie these distinct outcomes remain poorly understood. Here we show… read more here.
Keywords: cd8; cd8 cells; priming; effector cells ... See more keywords
FXR mediates T cell-intrinsic responses to reduced feeding during infection
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2020619117
Abstract: Significance Anorexia or decreased appetite is a common feature of infection. The effects of acute nutritional stress on effector T cells, which are required for pathogen-specific responses and protective immunological memory, are not fully understood.… read more here.
Keywords: fxr; effector cells; infection; cell intrinsic ... See more keywords