γδ T Cells Contribute to the Outcome of Murine Fulminant Viral Hepatitis via Effector Cytokines TNF-α and IFN-γ
Sign Up to like & getrecommendations! Published in 2018 at "Current Medical Science"
DOI: 10.1007/s11596-018-1926-x
Abstract: SummaryThe mechanisms involved in virus-induced severe hepatitis have not been fully elucidated. In this study, we investigated the role of gamma delta T cell receptors (γδ) T cells in the pathogenesis of fulminant viral hepatitis… read more here.
Keywords: cytokines tnf; hepatitis; fulminant viral; effector cytokines ... See more keywords
OP0229 GUSELKUMAB INDUCES SUSTAINED REDUCTION IN ACUTE PHASE PROTEINS AND TH17 EFFECTOR CYTOKINES IN ACTIVE PSORIATIC ARTHRITIS IN TWO PHASE-3 CLINICAL TRIALS (DISCOVER-1 AND DISCOVER-2)
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.1240
Abstract: Guselkumab (GUS), an IL-23 inhibitor monoclonal antibody (Mab) that specifically binds to the IL-23p19 subunit, demonstrated efficacy compared to placebo (PBO) in reducing skin and musculoskeletal signs and symptoms in patients (pts) with active psoriatic… read more here.
Keywords: janssen research; effector cytokines; 17a 17f; employee janssen ... See more keywords
Guselkumab induces robust reduction in acute phase proteins and type 17 effector cytokines in active psoriatic arthritis: results from phase 3 trials
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DOI: 10.1136/rmdopen-2021-001679
Abstract: Objective To investigate serum protein expression in participants with psoriatic arthritis (PsA) and changes after guselkumab treatment. Methods Participants with PsA were treated with guselkumab or placebo in the DISCOVER-1 and DISCOVER-2 studies. Serum levels… read more here.
Keywords: acute phase; 17a 17f; treatment; effector cytokines ... See more keywords