Acetate Promotes T Cell Effector Function during Glucose Restriction.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.04.022
Abstract: Competition for nutrients like glucose can metabolically restrict T cells and contribute to their hyporesponsiveness during cancer. Metabolic adaptation to the surrounding microenvironment is therefore key for maintaining appropriate cell function. For instance, cancer cells use… read more here.
Keywords: function glucose; effector function; promotes cell; function ... See more keywords
Using CRISPR to enhance T cell effector function for therapeutic applications
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cytox.2020.100049
Abstract: T cells are critical to fight pathogenic microbes and combat malignantly transformed cells in the fight against cancer. To exert their effector function, T cells produce effector molecules, such as the pro-inflammatory cytokines IFN-γ, TNF-α… read more here.
Keywords: enhance cell; cell; effector function; effector ... See more keywords
Beyond Viral Neutralization.
Sign Up to like & getrecommendations! Published in 2017 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2016.0299
Abstract: It has been known for more than 30 years that HIV-1 infection drives a very potent B cell response resulting in the production of anti-HIV-1 antibodies targeting several viral proteins, particularly its envelope glycoproteins (Env).… read more here.
Keywords: antibody; effector function; mediated effector; neutralizing antibodies ... See more keywords
The histone demethylase Utx controls CD8+ T-cell-dependent antitumor immunity via epigenetic regulation of the effector function.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer science"
DOI: 10.1111/cas.15814
Abstract: CD8+ T cells play a central role in antitumor immune responses. Epigenetic gene regulation is essential to acquire the effector function of CD8+ T cells. However, the role of Utx, a demethylase of histone H3K27,… read more here.
Keywords: effector function; antitumor; cd8 cells; effector ... See more keywords
Defective N-glycosylation in tumor-infiltrating CD8+ T cells impairs IFN-γ-mediated effector function.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and cell biology"
DOI: 10.1111/imcb.12647
Abstract: T cell-mediated antitumor immunity is modulated, in part, by N-glycosylation. However, the interplay between N-glycosylation and the loss of effector function in exhausted T cells has not yet been fully investigated. Here, we delineated the… read more here.
Keywords: effector function; tumor infiltrating; glycosylation; cd8 cells ... See more keywords
Decoupling the role of RORγt in the differentiation and effector function of TH17 cells
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.adc9221
Abstract: RORγt is known to instruct the differentiation of T helper 17 (TH17) cells that mediate the pathogenesis of autoimmune diseases. However, it remains unknown whether RORγt plays a distinct role in the differentiation and effector… read more here.
Keywords: th17 cells; effector function; ror; function th17 ... See more keywords
Abstract 3826: GITRL-Fc biomarker and mechanism study: GITRL-Fc reduces Treg frequency in tumors and requires effector function for inhibition of tumor growth
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1158/1538-7445.am2018-3826
Abstract: Activation of the co-stimulatory receptor GITR (Glucocorticoid-Induced Tumor Necrosis Factor Receptor) by GITR-Ligand (GITRL) promotes proliferation and activation of effector T cells (T eff) and inhibits suppressive activity of regulatory T cells (Treg). Here, we… read more here.
Keywords: frequency; gitrl; effector function; tumor ... See more keywords
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-18-0351
Abstract: Expression of TIGIT and PD-1 correlates with impaired T-cell effector function in intratumoral T cells. TIGIT and PD-1 ligands are expressed in the tumor microenvironment. Combinatorial blockade of TIGIT and PD-1 may be a useful… read more here.
Keywords: cell non; effector function; intratumoral cells; lymphoma ... See more keywords
IgG3 collaborates with IgG1 and IgA to recruit effector function in RV144 vaccinees
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.140925
Abstract: While the RV144 HIV vaccine trial led to moderately reduced risk of HIV acquisition, emerging data from the HVTN702 trial point to the critical need to reexamine RV144-based correlates of reduced risk of protection. While… read more here.
Keywords: igg1; iga; igg3; rv144 ... See more keywords
Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity.
Sign Up to like & getrecommendations! Published in 2023 at "Cell metabolism"
DOI: 10.2139/ssrn.4187261
Abstract: Augmented T cell function leading to host damage in autoimmunity is supported by metabolic dysregulation, making targeting immunometabolism an attractive therapeutic avenue. Canagliflozin, a type 2 diabetes drug, is a sodium glucose co-transporter 2 (SGLT2) inhibitor… read more here.
Keywords: cell; function; effector function; autoimmunity ... See more keywords
Targeting TRIM29 As a Negative Regulator of CAR-NK Cell Effector Function to Improve Antitumor Efficacy of These Cells: A Perspective.
Sign Up to like & getrecommendations! Published in 2023 at "Current molecular medicine"
DOI: 10.2174/1566524023666230510101525
Abstract: Natural killer (NK) cells are among the most important cells in innate immune defense. In contrast to T cells, the effector function of NK cells does not require prior stimulation and is not MHC restricted.… read more here.
Keywords: cell; effector function; car; cell effector ... See more keywords