N‐glycan engineering of a plant‐produced anti‐CD20‐hIL‐2 immunocytokine significantly enhances its effector functions
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26503
Abstract: Anti‐CD20 recombinant antibodies are among the most promising therapeutics for the treatment of B‐cell malignancies such as non‐Hodgkin lymphomas. We recently demonstrated that an immunocytokine (2B8‐Fc‐hIL2), obtained by fusing an anti‐CD20 scFv‐Fc antibody derived from… read more here.
Keywords: plant; effector functions; glycosylation; anti cd20 ... See more keywords
Expression of IgG Monoclonals with Engineered Immune Effector Functions.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8648-4_16
Abstract: The therapeutic development of monoclonal antibodies requires robust and reliable methods for their recombinant expression and characterization. In this context, an increasingly important aspect in the antibody development process is to determine the contribution of… read more here.
Keywords: expression igg; effector functions; immune effector; monoclonals engineered ... See more keywords
Chemoenzymatic Defucosylation of Therapeutic Antibodies for Enhanced Effector Functions Using Bacterial α-Fucosidases.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8648-4_19
Abstract: Core fucosylation plays a critical role in modulating the effector functions of therapeutic antibodies such as the antibody-dependent cellular cytotoxicity (ADCC) through adversely affecting the affinity of antibodies for Fcγ receptors. Thus, a facile method… read more here.
Keywords: therapeutic antibodies; bacterial fucosidases; herceptin; effector functions ... See more keywords
Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.08.068
Abstract: Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor immunosurveillance. Here, we report that melanoma patients with high expression of glycolysis-related genes show a worse progression free survival upon anti-PD1… read more here.
Keywords: checkpoint therapy; glycolysis preserves; glycolysis; effector functions ... See more keywords
A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2022 at "Cell Reports"
DOI: 10.1016/j.celrep.2022.110368
Abstract: Emerging evidence indicate that both neutralizing and Fc-mediated effector functions of antibodies contribute to protection against SARS-CoV-2. It is unclear if Fc-effector functions alone can protect against SARS-CoV-2. Here, we isolated CV3-13, a non-neutralizing antibody,… read more here.
Keywords: sars cov; non neutralizing; delays virus; neutralizing antibody ... See more keywords
Control of memory CD8+ T cell longevity and effector functions by IL-15.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.11.011
Abstract: IL-15 is a member of the common gamma chain family of cytokines and plays important roles in regulating several aspects of innate and adaptive immunity. Besides its established role in controlling homeostatic proliferation and survival… read more here.
Keywords: memory cd8; cell; memory; effector functions ... See more keywords
An appraisal of antigen identification and IgG effector functions driving host immune responses in multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2021 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2021.103328
Abstract: Increased immunoglobulin G (IgG) antibodies and oligoclonal bands (OCB) are the most characteristic features of multiple sclerosis (MS), a neuroinflammatory demyelinating disease with neurodegeneration at chronic stages. OCB are shown to be associated with disease… read more here.
Keywords: igg; effector functions; antigen identification; multiple sclerosis ... See more keywords
T-cells produce acidic niches in lymph nodes to suppress their own effector functions
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17756-7
Abstract: The acidic pH of tumors profoundly inhibits effector functions of activated CD8 + T-cells. We hypothesize that this is a physiological process in immune regulation, and that it occurs within lymph nodes (LNs), which are likely acidic… read more here.
Keywords: lymph nodes; effector functions; acidic niches; activation ... See more keywords
Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28250-7
Abstract: Increasingly, antibodies are being used to treat and prevent viral infections. In the context of HIV, efficacy is primarily attributed to dose-dependent neutralization potency and to a lesser extent Fc-mediated effector functions. It remains unclear… read more here.
Keywords: hiv antibody; antibody; antibody associated; effector functions ... See more keywords
Metabolic changes of Interleukin-12/15/18-stimulated human NK cells
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DOI: 10.1038/s41598-021-85960-6
Abstract: Natural Killer (NK) cells acquire memory-like properties following a brief stimulation with IL-12, IL-15 and IL-18. These IL-12/15/18-preactivated NK cells, also known as cytokine-induced memory-like (CIML) NK cells, have been revealed as a powerful tool… read more here.
Keywords: stimulated human; changes interleukin; effector functions; metabolic changes ... See more keywords
Study on antibody Fc-glycosylation for optimal effector functions.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00672g
Abstract: A comprehensive structure-activity relationship study on antibody Fc-glycosylation has been performed using the chimeric anti-SSEA4 antibody chMC813-70 as a model. The α-2,6 sialylated biantennary complex type glycan was identified as the optimal Fc-glycan with significant… read more here.
Keywords: glycosylation optimal; study antibody; effector functions; antibody glycosylation ... See more keywords