Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions.
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2016.11.008
Abstract: Chinese hamster ovary (CHO) cells are the preferred cell factory for the production of therapeutic glycoproteins. Although efforts primarily within bioprocess optimization have led to increased product titers of recombinant proteins (r-proteins) expressed in CHO… read more here.
Keywords: effector genes; hamster ovary; chinese hamster; ectopic expression ... See more keywords
Genetic risk of osteoarthritis operates during human skeletogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac251
Abstract: Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of cartilage within articular joints. Although a leading cause of disability, there are no disease-modifying therapies. Evidence is emerging to support the… read more here.
Keywords: cartilage; osteoarthritis; risk; effector genes ... See more keywords
Plant secondary metabolite citral interferes with Phytophthora capsici virulence by manipulating the expression of effector genes.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular plant pathology"
DOI: 10.1111/mpp.13340
Abstract: Phytophthora capsici is a notorious pathogen that infects various economically important plants and causes serious threats to agriculture worldwide. Plants deploy a variety of plant secondary metabolites to fend off pathogen attacks, but the molecular… read more here.
Keywords: plant secondary; expression; phytophthora capsici; effector genes ... See more keywords
Historical genomics reveals the evolutionary mechanisms behind multiple outbreaks of the host-specific coffee wilt pathogen Fusarium xylarioides
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DOI: 10.1186/s12864-021-07700-4
Abstract: Background Nearly 50% of crop yields are lost to pests and disease, with plants and pathogens locked in an amplified co-evolutionary process of disease outbreaks. Coffee wilt disease, caused by Fusarium xylarioides , decimated coffee… read more here.
Keywords: coffee wilt; effector genes; fusarium xylarioides; coffee ... See more keywords
Effector Repertoire of Phytophthora betacei: In Search of Possible Virulence Factors Responsible for Its Host Specificity
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DOI: 10.3389/fgene.2020.00579
Abstract: Phytophthora betacei is an oomycete plant pathogen closely related to Phytophthora infestans. It infects tree tomato (Solanum betaceum) in northern South America, but is, under natural conditions, unable to infect potatoes or tomatoes, the main… read more here.
Keywords: phytophthora species; effector genes; host; repertoire ... See more keywords
Inhibition of specific signaling pathways rather than epigenetic silencing of effector genes is the leading mechanism of innate tolerance
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1006002
Abstract: Introduction Macrophages activated through a pattern-recognition receptor (PRR) enter a transient state of tolerance characterized by diminished responsiveness to restimulation of the same receptor. Signaling-based and epigenetic mechanisms are invoked to explain this innate tolerance.… read more here.
Keywords: silencing effector; inhibition; innate tolerance; tolerance ... See more keywords
Non-parent of Origin Expression of Numerous Effector Genes Indicates a Role of Gene Regulation in Host Adaption of the Hybrid Triticale Powdery Mildew Pathogen
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2018.00049
Abstract: Powdery mildew is an important disease of cereals. It is caused by one species, Blumeria graminis, which is divided into formae speciales each of which is highly specialized to one host. Recently, a new form… read more here.
Keywords: effector genes; expression; host; gene ... See more keywords