Fungal effector genes involved in the suppression of chitin signaling as novel targets for the control of powdery mildew disease via a nontransgenic RNA interference approach
Sign Up to like & getrecommendations! Published in 2025 at "Pest Management Science"
DOI: 10.1002/ps.8660
Abstract: Chitin is a crucial component of fungal cell walls and an effective elicitor of plant immunity; however, phytopathogenic fungi have developed virulence mechanisms to counteract the activation of this plant defensive response. In this study,… read more here.
Keywords: powdery mildew; chitin; effector genes; fungal effector ... See more keywords
Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions.
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2016.11.008
Abstract: Chinese hamster ovary (CHO) cells are the preferred cell factory for the production of therapeutic glycoproteins. Although efforts primarily within bioprocess optimization have led to increased product titers of recombinant proteins (r-proteins) expressed in CHO… read more here.
Keywords: effector genes; hamster ovary; chinese hamster; ectopic expression ... See more keywords
Genetic risk of osteoarthritis operates during human skeletogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac251
Abstract: Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of cartilage within articular joints. Although a leading cause of disability, there are no disease-modifying therapies. Evidence is emerging to support the… read more here.
Keywords: cartilage; osteoarthritis; risk; effector genes ... See more keywords
Transcription factor Rel regulates the transcription of effector genes involved in immune response by cooperating with IκBs in lamprey (Lethenteron reissneri).
Sign Up to like & getrecommendations! Published in 2025 at "Journal of immunology"
DOI: 10.1093/jimmun/vkae060
Abstract: The Rels, a class of nuclear factor κB (NF-κB) complexes, regulate diverse physiological processes by modulating the transcription of effector genes. IκBs are the critical proteins that inhibit NF-κB nuclear translocation, thereby disrupting NF-κB-mediated signaling… read more here.
Keywords: effector genes; factor; rel; transcription ... See more keywords
OA30 Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel effector genes
Sign Up to like & getrecommendations! Published in 2024 at "Rheumatology"
DOI: 10.1093/rheumatology/keae163.030
Abstract: Osteoarthritis is a complex disease with a huge public health burden. Genome-wide association studies (GWAS) have identified hundreds of osteoarthritis-associated sequence variants, but the effector genes underpinning these signals remain largely elusive. Understanding chromosome organisation… read more here.
Keywords: none; effector genes; map; primary osteoarthritis ... See more keywords
Occurrence of type VI secretion system effector genes in longitudinal isolates of P. aeruginosa from people with cystic fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Microbial Genomics"
DOI: 10.1099/mgen.0.001555
Abstract: Abstract Pseudomonas aeruginosa uses multiple type VI secretion systems (T6SSs) to manipulate eukaryotic cells, kill competing microbes and take up nutrients. Bacterial strains are known to differ in their T6SS apparatus and the toxic effector… read more here.
Keywords: type secretion; effector genes; effector; cystic fibrosis ... See more keywords
Plant secondary metabolite citral interferes with Phytophthora capsici virulence by manipulating the expression of effector genes.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular plant pathology"
DOI: 10.1111/mpp.13340
Abstract: Phytophthora capsici is a notorious pathogen that infects various economically important plants and causes serious threats to agriculture worldwide. Plants deploy a variety of plant secondary metabolites to fend off pathogen attacks, but the molecular… read more here.
Keywords: plant secondary; expression; phytophthora capsici; effector genes ... See more keywords
A MYB‐related transcription factor regulates effector gene expression in an oomycete pathogen
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Plant Pathology"
DOI: 10.1111/mpp.13468
Abstract: Abstract Phytophthora pathogens possess hundreds of effector genes that exhibit diverse expression patterns during infection, yet how the expression of effector genes is precisely regulated remains largely elusive. Previous studies have identified a few potential… read more here.
Keywords: expression; myb related; effector genes; transcription factor ... See more keywords
Historical genomics reveals the evolutionary mechanisms behind multiple outbreaks of the host-specific coffee wilt pathogen Fusarium xylarioides
Sign Up to like & getrecommendations! Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-021-07700-4
Abstract: Background Nearly 50% of crop yields are lost to pests and disease, with plants and pathogens locked in an amplified co-evolutionary process of disease outbreaks. Coffee wilt disease, caused by Fusarium xylarioides , decimated coffee… read more here.
Keywords: coffee wilt; effector genes; fusarium xylarioides; coffee ... See more keywords
Effector Repertoire of Phytophthora betacei: In Search of Possible Virulence Factors Responsible for Its Host Specificity
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.00579
Abstract: Phytophthora betacei is an oomycete plant pathogen closely related to Phytophthora infestans. It infects tree tomato (Solanum betaceum) in northern South America, but is, under natural conditions, unable to infect potatoes or tomatoes, the main… read more here.
Keywords: phytophthora species; effector genes; host; repertoire ... See more keywords
Inhibition of specific signaling pathways rather than epigenetic silencing of effector genes is the leading mechanism of innate tolerance
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1006002
Abstract: Introduction Macrophages activated through a pattern-recognition receptor (PRR) enter a transient state of tolerance characterized by diminished responsiveness to restimulation of the same receptor. Signaling-based and epigenetic mechanisms are invoked to explain this innate tolerance.… read more here.
Keywords: silencing effector; inhibition; innate tolerance; tolerance ... See more keywords