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   Articles with "effector memory" as a keyword



Musings on mania: A role for T-lymphocytes?

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recommendations! Published in 2018 at "Brain, Behavior, and Immunity"

DOI: 10.1016/j.bbi.2018.05.019

Abstract: The pathophysiological basis of hypomania/mania and its link with immune dysregulation has been sparsely investigated and is poorly understood. Magioncalda et al. (2018) narrow this gap by quantifying white matter (WM) pathology together with the… read more here.

Keywords: cell; cd8; pathology; effector memory ... See more keywords

Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.03.084

Abstract: SUMMARY T cells compete with malignant cells for limited nutrients within the solid tumor microenvironment. We found that effector memory CD4 T cells respond distinctly from other T cell subsets to limiting glucose and can… read more here.

Keywords: metabolism; fatty acid; cell subsets; differential reliance ... See more keywords
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Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory.

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recommendations! Published in 2022 at "Cell reports"

DOI: 10.1016/j.celrep.2022.110632

Abstract: Differential interleukin-2 (IL-2) signaling and production are associated with disparate effector and memory fates. Whether the IL-2 signals perceived by CD8 T cells come from autocrine or paracrine sources, the timing of IL-2 signaling and their… read more here.

Keywords: cd8 cell; cd8 cells; memory; cell ... See more keywords
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Reference Genes for Expression Studies in Human CD8+ Naïve and Effector Memory T Cells under Resting and Activating Conditions

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-66367-1

Abstract: Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is widely used for mRNA quantification. To accurately measure changing gene transcript levels under different experimental conditions, the use of appropriate reference gene transcripts is instrumental. In T… read more here.

Keywords: reference genes; reference; reference gene; activating conditions ... See more keywords

Developmental epigenetic programming by Tet1/3 determines peripheral CD8 T cell fate

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recommendations! Published in 2025 at "EMBO Reports"

DOI: 10.1038/s44319-025-00439-z

Abstract: In response to infections, naive CD8 T cells give rise to effector and memory T cells. However, eliciting long-lived memory CD8 T cells remains a challenge for many infections. DNA demethylation of cytosines within CpG… read more here.

Keywords: cd8; tet1; effector; effector memory ... See more keywords

Regulation of CD45 isoforms during human effector and memory CD8 T cell differentiation: Implications for T cell nomenclature

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2322982122

Abstract: Significance CD45 isoforms are used to distinguish between naïve (CD45RA) and effector T cells (CD45RO), and in combination with CCR7 expression to define the canonical effector memory (CD45RO+CCR7-) and central memory (CD45RO+CCR7+) T cells subset.… read more here.

Keywords: memory; memory cd8; effector; effector memory ... See more keywords

Lower absolute numbers of CD4+ naïve and CD8+ effector memory cells in peripheral blood are potential predictive indicators of renal endpoint events in patients with chronic kidney disease

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recommendations! Published in 2025 at "Renal Failure"

DOI: 10.1080/0886022x.2025.2552914

Abstract: Abstract Background: There is no consensus on the distribution of T cell subsets during chronic kidney disease (CKD) progression. In this study, we aimed to investigate the levels of circulating T cell subsets in the… read more here.

Keywords: peripheral blood; memory; effector memory; cell ... See more keywords

IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with limited cytokine release

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recommendations! Published in 2024 at "mAbs"

DOI: 10.1080/19420862.2024.2395499

Abstract: ABSTRACT T cell engagers (TCEs) are becoming an integral class of biological therapeutic owing to their highly potent ability to eradicate cancer cells. Nevertheless, the widespread utility of classical CD3-targeted TCEs has been limited by… read more here.

Keywords: effector memory; cancer; cytokine release;

Crohn's Disease Patients Uniquely Contain Inflammatory Responses to Flagellin in a CD4 Effector Memory Subset.

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recommendations! Published in 2022 at "Inflammatory bowel diseases"

DOI: 10.1093/ibd/izac146

Abstract: BACKGROUND Specific microbial antigens stimulate production of antibodies indicative of the aberrant immune response in Crohn's disease (CD). We tested for T cell reactivity linkage to B cell responses and now report on the prevalence,… read more here.

Keywords: cd4; effector memory; disease; crohn disease ... See more keywords
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Platelet factor 4 enhances CD4+ T effector memory cell responses via Akt‐PGC1α‐TFAM signaling‐mediated mitochondrial biogenesis

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recommendations! Published in 2020 at "Journal of Thrombosis and Haemostasis"

DOI: 10.1111/jth.15005

Abstract: Cell metabolism drives T cell functions, while platelets regulate overall CD4+ T cell immune responses. read more here.

Keywords: factor enhances; effector memory; enhances cd4; cd4 effector ... See more keywords

Percentages of Effector Memory T Cells in Peripheral Blood Associated With Non‐Infectious Comorbidities in Common Variable Immunodeficiency Disorders

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recommendations! Published in 2025 at "Scandinavian Journal of Immunology"

DOI: 10.1111/sji.70037

Abstract: Common variable immunodeficiency disorders (CVID) are characterized by hypogammaglobulinemia and increased susceptibility to infections. However, non‐infectious comorbidities (NICM) are also frequent manifestations of the disease. We search for distinctive immunophenotypes in CVID patients with NICM.… read more here.

Keywords: common variable; effector memory; variable immunodeficiency; blood ... See more keywords