Strong influenza-induced TFH generation requires CD4 effectors to recognize antigen locally and receive signals from continuing infection
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111064119
Abstract: Significance Influenza infection elicits strong, long-lived protective antibodies, but most current influenza vaccines give weaker, short-lived protection. We noted that live virus is still replicating, making antigen and causing inflammation at 7 d postinfection (dpi),… read more here.
Keywords: infection; antigen; effector phase; tfh ... See more keywords
AB0098 THE EFFECT OF MALT1-DEFICIENCY ON THE EFFECTOR PHASE OF EXPERIMENTAL AUTOIMMUNE ARTHRITIS
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.1439
Abstract: Background: The paracaspase Malt1 is a cysteine protease, which forms a complex leading to the activation of the in proinflammatory transcription factor NF-κB in lymphocytes with CARMA1 and Bcl10. Previously, we showed that the myeloid… read more here.
Keywords: autoantibody; deficiency; arthritis; effector phase ... See more keywords
NKG2D signaling certifies effector CD8 T cells for memory formation
Sign Up to like & getrecommendations! Published in 2019 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-019-0531-2
Abstract: BackgroundThe development of memory responses is an evolutionary function of the adaptive immune system. We propose that for the immune system to populate the memory compartment with the best-suited CD8 T cells it utilizes a… read more here.
Keywords: nkg2d signaling; cd8 cells; formation; effector phase ... See more keywords