Mutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets
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DOI: 10.1038/s41598-019-45202-2
Abstract: Development of drugs that allosterically regulate enzyme functions to treat disease is a costly venture. Amino acid susbstitutions that mimic allosteric effectors in vitro will identify therapeutic regulatory targets enhancing the likelihood of developing a… read more here.
Keywords: hlpyk; effectors genome; point mutations; allosteric effectors ... See more keywords