Calcium signals between the ryanodine receptor- and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the ensuing survival vs apoptotic signaling
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DOI: 10.1016/j.redox.2018.10.015
Abstract: A low concentration of arsenite (6 h), selectively stimulating the intraluminal crosstalk between the inositol-1, 4, 5-triphosphate receptor and the ryanodine receptor (RyR), increased the mitochondrial transport of RyR-derived Ca2+ through the mitochondrial Ca2+ uniporter. This… read more here.
Keywords: effects arsenite; formation; receptor; mitochondrial ca2 ... See more keywords
Synergistic Effects of Arsenite on Radiosensitization of Glioblastoma Cells.
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DOI: 10.21873/anticanres.11798
Abstract: BACKGROUND/AIM Glioblastoma is a frequent type of brain tumor and is radioresistant. Arsenite, which crosses the blood-brain barrier, shows synergistic effects with radiation in vitro and in vivo. The mechanism remains unclear. MATERIALS AND METHODS… read more here.
Keywords: arsenite radiosensitization; radiosensitization; effects arsenite; synergistic effects ... See more keywords