Fingolimod Immune Effects Beyond Its Sequestration Ability
Sign Up to like & getrecommendations! Published in 2019 at "Neurology and Therapy"
DOI: 10.1007/s40120-019-00162-7
Abstract: Fingolimod is the first orally administered drug approved for the treatment of relapsing–remitting multiple sclerosis (MS). This drug, modulating sphingosine receptors, regulates the trafficking of lymphocytes between primary and secondary lymphoid organs, trapping naïve T… read more here.
Keywords: beyond sequestration; fingolimod immune; memory cells; fingolimod ... See more keywords
Distributional causal effects: Beyond an "averagarian" view of intervention effects.
Sign Up to like & getrecommendations! Published in 2022 at "Psychological methods"
DOI: 10.1037/met0000533.supp
Abstract: The usefulness of mean aggregates in the analysis of intervention effectiveness is a matter of considerable debate in the psychological, educational, and social sciences. In addition to studying "average treatment effects," the evaluation of "distributional… read more here.
Keywords: distributional causal; beyond averagarian; effects beyond; causal effects ... See more keywords
Neighbourhood effects and beyond: Explaining the paradoxes of inequality in the changing American metropolis
Sign Up to like & getrecommendations! Published in 2019 at "Urban Studies"
DOI: 10.1177/0042098018795363
Abstract: American cities today are simultaneously the same and different from Wilson’s classic portrayal in The Truly Disadvantaged ([1987] 2012), first published over 30 years ago. Concentrated poverty and racial segregation endure, as do racial gaps… read more here.
Keywords: explaining paradoxes; neighbourhood effects; beyond explaining; paradoxes inequality ... See more keywords
Placebo effects beyond dopamine
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002812
Abstract: The role of dopamine in reward expectancy has led to the hypothesis that it is crucial for forming treatment expectations and placebo effects. However, a new study in PLOS Biology presents robust evidence against the… read more here.
Keywords: placebo effects; beyond dopamine; biology; effects beyond ... See more keywords
New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22179453
Abstract: Under metabolic stress conditions such as hypoxia and glucose deprivation, an increase in the AMP:ATP ratio activates the AMP-activated protein kinase (AMPK) pathway, resulting in the modulation of cellular metabolism. Metformin, which is widely prescribed… read more here.
Keywords: ampk pathway; diabetic retinopathy; nonapoptotic cell; effects beyond ... See more keywords