Effects of cocaine and levamisole (as adulterant) on the isolated perfused Langendorff heart
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DOI: 10.1007/s00414-020-02300-5
Abstract: Cocaine-related deaths occur regularly in forensic routine work. In cases in which the detected concentration of cocaine is rather low and other causes of death apart from intoxication can be ruled out, the question arises… read more here.
Keywords: heart; perfused langendorff; langendorff heart; cocaine ... See more keywords
Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine.
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DOI: 10.1016/j.drugalcdep.2017.03.014
Abstract: BACKGROUND Cocaine addiction is a chronic brain disease affecting neurotransmission. Muscarinic cholinergic receptors modulate dopaminergic signaling in the reward system, and muscarinic receptor stimulation can block direct reinforcing effects of cocaine. Here, we tested the… read more here.
Keywords: allosteric modulators; muscarinic receptor; cocaine; effects cocaine ... See more keywords
Dopamine D2 receptors mediate the increase in reinstatement of the conditioned rewarding effects of cocaine induced by acute social defeat
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DOI: 10.1016/j.ejphar.2017.01.039
Abstract: Abstract Social stress modifies the activity of brain areas involved in the rewarding effects of psychostimulants, inducing neuroadaptations in the dopaminergic mesolimbic system and modifying the sensitivity of dopamine receptors. In the present study we… read more here.
Keywords: effects cocaine; cocaine induced; dopamine receptors; rewarding effects ... See more keywords
Effects of ketosis on cocaine-induced reinstatement in male mice
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DOI: 10.1016/j.neulet.2022.136619
Abstract: In recent years, the benefits of the ketogenic diet (KD) on different psychiatric disorders have been gaining attention, but the substance abuse field is still unexplored. Some studies have reported that palatable food can modulate… read more here.
Keywords: effects cocaine; induced reinstatement; effects ketosis; ketosis cocaine ... See more keywords
Critical role of TLR4 in uncovering the increased rewarding effects of cocaine and ethanol induced by social defeat in male mice
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DOI: 10.1016/j.neuropharm.2020.108368
Abstract: BACKGROUND Substance use disorders and social stress are currently associated with changes in the immune system response by which they induce a proinflammatory state in neurons and glial cells that eventually modulates the reward system.… read more here.
Keywords: social defeat; rewarding effects; role; induced social ... See more keywords
Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior
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DOI: 10.1038/s41398-021-01693-0
Abstract: Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn 2+ ) also binds to the DAT, but the in vivo relevance of this interaction is unknown. We… read more here.
Keywords: potentiates effects; neurotransmission; mice; cocaine ... See more keywords
ProSAAS‐derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine
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DOI: 10.1111/jnc.14209
Abstract: To identify neuropeptides that are regulated by cocaine, we used a quantitative peptidomic technique to examine the relative levels of neuropeptides in several regions of mouse brain following daily intraperitoneal administration of 10 mg/kg cocaine… read more here.
Keywords: prosaas; prosaas derived; regulated cocaine; cocaine ... See more keywords
Deletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine
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DOI: 10.15252/embr.201745089
Abstract: Melanoma antigen genes (Mage) were first described as tumour markers. However, some of Mage are also expressed in healthy cells where their functions remain poorly understood. Here, we describe an unexpected role for one of… read more here.
Keywords: abolishes locomotor; deletion maged1; mice abolishes; mice ... See more keywords