Effects of CYP2C19 and CYP3A5 genetic polymorphisms on the pharmacokinetics of cilostazol and its active metabolites
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DOI: 10.1007/s00228-018-2522-5
Abstract: PurposeCYP3A4, CYP2C19, and CYP3A5 are primarily involved in the metabolism of cilostazol. We investigated the effects of CYP2C19 and CYP3A5 genetic polymorphisms on the pharmacokinetics of cilostazol and its two active metabolites.MethodsThirty-three healthy Korean volunteers… read more here.
Keywords: polymorphisms pharmacokinetics; cyp2c19 cyp3a5; active metabolites; cyp3a5 genetic ... See more keywords
Effects of CYP2C19*17 genetic polymorphisms on plasma and saliva concentrations of diazepam in patients with alcohol withdrawal syndrome
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DOI: 10.1097/ypg.0000000000000306
Abstract: Introduction Diazepam is one of the most commonly prescribed tranquilizers for the therapy of alcohol withdrawal syndrome (AWS). However, diazepam therapy often turns out to be ineffective, and some patients experience dose-dependent adverse drug reactions.… read more here.
Keywords: alcohol withdrawal; cyp2c19 genetic; genetic polymorphisms; withdrawal syndrome ... See more keywords
Effects of CYP2C19 genetic polymorphisms on the pharmacokinetics of lacosamide in Korean patients with epilepsy
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DOI: 10.1111/epi.17399
Abstract: Many pharmacokinetic studies of lacosamide (LCM) have been reported, but no large‐scale clinical study has been conducted on genetic polymorphisms that affect the metabolism of LCM. Therefore, we designed a pharmacogenetic study of LCM to… read more here.
Keywords: pharmacokinetics lacosamide; genetic polymorphisms; cyp2c19 genetic; polymorphisms pharmacokinetics ... See more keywords
Effects of CYP2C19 Variants on Fluoxetine Metabolism in vitro
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DOI: 10.1159/000475598
Abstract: Aims: CYP2C19 is an important member of the cytochrome P450 enzyme superfamily. We recently identified 31 CYP2C19 alleles in the Han Chinese population. The aim of this study was to assess the catalytic activities of… read more here.
Keywords: cyp2c19 variants; vitro; effects cyp2c19; cyp2c19 ... See more keywords
Corrigendum: Predicting the Effects of CYP2C19 and Carboxylesterases on Vicagrel, a Novel P2Y12 Antagonist, by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach
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DOI: 10.3389/fphar.2021.668861
Abstract: [This corrects the article DOI: 10.3389/fphar.2020.591854.]. read more here.
Keywords: corrigendum predicting; predicting effects; cyp2c19 carboxylesterases; carboxylesterases vicagrel ... See more keywords