Anticoagulant Effects of Dabigatran in Paediatric Patients Compared with Adults: Combined Data from Three Paediatric Clinical Trials
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DOI: 10.1055/s-0038-1668132
Abstract: Background  Physiological age-related changes in the haemostatic and coagulation systems result in differing anticoagulant assay responses to standard anticoagulants. Therefore, we investigated the response of anticoagulant assays to dabigatran etexilate (DE) in children compared with… read more here.
Keywords: data three; paediatric clinical; clinical trials; compared adults ... See more keywords
Effects of dabigatran according to age in atrial fibrillation
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DOI: 10.1136/heartjnl-2016-310358
Abstract: Objective The prevalence of atrial fibrillation (AF) and the risk of stroke and bleeding vary according to age. To estimate effects of dabigatran, compared with warfarin, on stroke, bleeding and mortality in patients with AF… read more here.
Keywords: atrial fibrillation; aged years; age; twice daily ... See more keywords
Effects of Simvastatin on Pharmacokinetics and Anticoagulant Effects of Dabigatran in Healthy Subjects
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DOI: 10.3390/ph16030364
Abstract: Higher risk of major hemorrhage associated with concomitant use of dabigatran and simvastatin compared to other statins was previously reported with a suggestion of P-glycoprotein-mediated interaction. The aim of this study was to evaluate the… read more here.
Keywords: pharmacokinetics anticoagulant; dabigatran; effects dabigatran; anticoagulant effects ... See more keywords