Are the effects of drugs to prevent and to treat heart failure always concordant? The statin paradox and its implications for understanding the actions of antidiabetic medications
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1183
Abstract: Most treatments for chronic heart failure are effective both in preventing its onset and reducing its progression. However, statins prevent the development of heart failure, but they do not decrease morbidity and mortality in those… read more here.
Keywords: heart; effects drugs; implications understanding; heart failure ... See more keywords
Assessment of the Effects of Drugs on Mitochondrial Respiration.
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DOI: 10.1007/978-1-0716-1270-5_9
Abstract: Mitochondria are targets of newly synthesized drugs and being tested for the treatment of various diseases caused or accompanied by disruption of cellular bioenergetics. In drug development, it is necessary to test for drug-induced changes… read more here.
Keywords: mitochondrial respiration; effects drugs; drugs mitochondrial; assessment effects ... See more keywords
In silico tools predict effects of drugs on bone remodelling
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DOI: 10.1038/s41584-020-0457-6
Abstract: Researchers have developed an in silico (computer) platform that couples tissue adaptation with cellular and molecular interactions to simulate bone adaptation to mechanical loading and progress and treatment of metabolic bone diseases. What is the… read more here.
Keywords: tools predict; predict effects; effects drugs; silico ... See more keywords
In silico profiling of systemic effects of drugs to predict unexpected interactions
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DOI: 10.1038/s41598-018-19614-5
Abstract: Identifying unexpected drug interactions is an essential step in drug development. Most studies focus on predicting whether a drug pair interacts or is effective on a certain disease without considering the mechanism of action (MoA).… read more here.
Keywords: profiling systemic; drug interactions; systemic effects; effects drugs ... See more keywords
Effects of drugs of abuse on the central neuropeptide Y system
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DOI: 10.1111/adb.12518
Abstract: JG is supported by a postdoctoral fellowship ‘Centro-07ST24-FEDER-002005’ financed by QREN. JM and SB are supported by PhD fellowships SFRH/BD/44817/2008 and SFRH/BD/63773/2009, respectively, from the Foundation for Science and Technology (FCT, Portugal), co-financed by QREN.… read more here.
Keywords: science; effects drugs; foundation science; financed qren ... See more keywords
Specific-class Skin Side-effects of Drugs Might Compromise Blinding in Randomized Controlled Trials
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DOI: 10.2340/actadv.v103.3364
Abstract: Abstract is missing (Short communication) read more here.
Keywords: effects drugs; specific class; class skin; drugs might ... See more keywords