Urinary metabolic disturbance in the olfactory bulbectomized rats and the modulatory effects of fluoxetine.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116751
Abstract: AIMS The present study aims to investigate the impacts of olfactory bulbectomy (OBX) on urinary metabolic profile and tryptophan metabolites in prefrontal cortex (PFC) of rats, and to explore the regulation effects of fluoxetine. MAIN… read more here.
Keywords: olfactory; metabolism; effects fluoxetine; urinary metabolic ... See more keywords
Sex and social status modify the effects of fluoxetine on socioemotional behaviors in Syrian hamsters and rhesus macaques
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2022.173362
Abstract: Social subordination increases risk for psychiatric disorders, while dominance increases resilience to these disorders. Fluoxetine, a selective serotonin (5HT) reuptake inhibitor whose actions are mediated in part by the 5HT1A receptor (5HT1AR), has sex- and… read more here.
Keywords: rhesus macaques; effects fluoxetine; social status; sex social ... See more keywords
Hippocampus-related effects of fluoxetine treatment under stressful vs enriched conditions
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Psychiatry"
DOI: 10.1038/mp.2017.69
Abstract: The hippocampus in fluoxetine-treated mice responds differently with regard to volume and cell numbers under stressful vs enriched conditions. To account for effects specific to defined septo-temporal segments of the hippocampus, dissected hippocampi were straightened… read more here.
Keywords: effects fluoxetine; related effects; fluoxetine treatment; hippocampus related ... See more keywords
Hemodynamic effects of fluoxetine in pulmonary arterial hypertension: an open label pilot study
Sign Up to like & getrecommendations! Published in 2020 at "Pulmonary Circulation"
DOI: 10.1177/2045894020971954
Abstract: In order to evaluate the therapeutic potential of fluoxetine in pulmonary arterial hypertension, 13 patients with pulmonary arterial hypertension underwent catheterization before and after 12 (N = 5) or 24 (N = 8) weeks fluoxetine therapy. No change was… read more here.
Keywords: arterial hypertension; effects fluoxetine; hemodynamic effects; pulmonary arterial ... See more keywords
Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0204980
Abstract: Previous research has shown that fibroblast growth factor 2 protein (FGF2) can act as an anxiolytic and anti-depressive agent in rodents. Levels of hippocampal FGF2 and FGF2 receptors are decreased in post-mortem brains of individuals… read more here.
Keywords: fgf2; effects fluoxetine; fibroblast growth; glucocorticoid receptors ... See more keywords
Ecotoxicological assessment of the effects of fluoxetine on Daphnia magna based on acute toxicity, multigenerational reproduction effects, and attraction-repellence responses.
Sign Up to like & getrecommendations! Published in 2022 at "Chemosphere"
DOI: 10.2139/ssrn.4157308
Abstract: Fluoxetine, a common pharmaceutical used as an antidepressant, is already considered potentially hazardous to biota due to its increasing use and detection in European, North American, and Asian rivers. We studied the effects of fluoxetine… read more here.
Keywords: fluoxetine daphnia; effects fluoxetine; daphnia magna; magna ... See more keywords
Effects of Fluoxetine on Hippocampal Neurogenesis and Neuroprotection in the Model of Global Cerebral Ischemia in Rats
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19010162
Abstract: A selective serotonin reuptake inhibitor, fluoxetine, has recently attracted a significant interest as a neuroprotective therapeutic agent. There is substantial evidence of improved neurogenesis under fluoxetine treatment of brain ischemia in animal stroke models. We… read more here.
Keywords: hippocampal neurogenesis; effects fluoxetine; cerebral ischemia; ischemia ... See more keywords
Requirement of hippocampal DG nNOS-CAPON dissociation for the anxiolytic and antidepressant effects of fluoxetine
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.70370
Abstract: Background: Adult hippocampal neurogenesis and synaptic plasticity are necessary for the behavioral response to the selective serotonin reuptake inhibitor (SSRI) fluoxetine, but the molecular mechanisms underlying these effects are only partially understood. Methods: Anxiety and… read more here.
Keywords: antidepressant effects; dissociation; anxiolytic antidepressant; capon ... See more keywords