Structural modification of ellipticine derivatives with alkyl groups of varying length is influential on their effects on human DNA topoisomerase II: a combined experimental and computational study
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02472-9
Abstract: The compounds reducing tumor cell viability and disrupting DNA topoisomerase reactions have been widely used in anticancer drug development. Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is a potent intercalating agent that interferes with nucleic acid processing through interaction with… read more here.
Keywords: ellipticine derivatives; dna topoisomerase; topoisomerase; effects human ... See more keywords
Effects of human activities on hydrological drought patterns in the Yangtze River Basin, China
Sign Up to like & getrecommendations! Published in 2020 at "Natural Hazards"
DOI: 10.1007/s11069-020-04206-2
Abstract: As an extremely important region for the socioeconomic development of China, the Yangtze River Basin (YRB) is vulnerable to climate change and natural disasters. In recent decades, hydrological droughts have jeopardized regional water supply, local… read more here.
Keywords: yangtze river; activities hydrological; river basin; hydrological droughts ... See more keywords
Epigallocatechin-3-gallate exhibits immunomodulatory effects in human primary T cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.132
Abstract: T cells secrete several inflammatory cytokines that play a critical role in the progression of atherosclerosis. Although green tea epigallocatechin-3-gallate (EGCG) exerts anti-inflammatory and anti-atherosclerotic effects in animals, few studies have identified the mechanism underlying… read more here.
Keywords: gallate exhibits; human primary; epigallocatechin gallate; primary cells ... See more keywords
Antiviral effects of human milk oligosaccharides: A review
Sign Up to like & getrecommendations! Published in 2020 at "International Dairy Journal"
DOI: 10.1016/j.idairyj.2020.104784
Abstract: Abstract Virus infections can threaten human life and health and often cause considerable losses to society. There are multiple ways for viruses to invade host cells. Therefore, it is immensely important to inhibit the contact… read more here.
Keywords: antiviral effects; milk oligosaccharides; human milk; effects human ... See more keywords
The immunoregulatory and neuroprotective effects of human adipose derived stem cells overexpressing IL-11 and IL-13 in the experimental autoimmune encephalomyelitis mice.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106808
Abstract: Multiple sclerosis (MS) is an inflammatory demyelination disease in the central nervous system (CNS) characterized by incomplete endogenous remyelination in the chronic phase. A shift of the balance between pro and anti-inflammatory cytokines is one… read more here.
Keywords: human adipose; derived stem; mice; effects human ... See more keywords
Effects of human activities on concentrations of culturable bioaerosols in indoor air environments
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Aerosol Science"
DOI: 10.1016/j.jaerosci.2016.11.008
Abstract: Abstract We studied the effects of human activity on concentrations of fungal and bacterial bioaerosols in indoor air environments. We conducted measurement experiments for concentrations of bioaerosols and aerosol particles in test chambers with people… read more here.
Keywords: air environments; human activities; effects human; bioaerosols indoor ... See more keywords
Exhaustive search for epistatic effects on the human methylome
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13256-9
Abstract: Studies assessing the existence and magnitude of epistatic effects on complex human traits provide inconclusive results. The study of such effects is complicated by considerable increase in computational burden, model complexity, and model uncertainty, which… read more here.
Keywords: search epistatic; epistatic effects; exhaustive search; effects human ... See more keywords
Exposure to emamectin benzoate confers cytotoxic effects on human molt-4 T-cells and possible ameliorative role of vitamin E and dithiothreitol
Sign Up to like & getrecommendations! Published in 2022 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2022.2044350
Abstract: Abstract Emamectin benzoate (EMB) is an avermectin insecticide that is extensively used for pest control, but there are few reports concerning its cytotoxic effects on human lymphocytes. In the current study, the hematotoxicity of EMB… read more here.
Keywords: cell; cytotoxic effects; effects human; emamectin benzoate ... See more keywords
Advancing the Science on the Biopsychosocial Effects of Human Trafficking
Sign Up to like & getrecommendations! Published in 2018 at "Behavioral Medicine"
DOI: 10.1080/08964289.2018.1465269
Abstract: The issue of human trafficking gained global public and governance consciousness in the 1990s and reached a significant milestone at the beginning of the twenty-first century when the United Nation... read more here.
Keywords: medicine; advancing science; science biopsychosocial; effects human ... See more keywords
Possible health effects on the human brain by various generations of mobile telecommunication: a review based estimation of 5G impact
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2022.2026516
Abstract: Abstract Purpose The deployment of new 5G NR technology has significantly raised public concerns in possible negative effects on human health by radiofrequency electromagnetic fields (RF EMF). The current review is aimed to clarify the… read more here.
Keywords: health; possible health; health effects; telecommunication ... See more keywords
Functional effects of human milk oligosaccharides (HMOs)
Sign Up to like & getrecommendations! Published in 2023 at "Gut Microbes"
DOI: 10.1080/19490976.2023.2186115
Abstract: ABSTRACT Human milk oligosaccharides (HMOs) are the third most important solid component in human milk and act in tandem with other bioactive components. Individual HMO levels and distribution vary greatly between mothers by multiple variables,… read more here.
Keywords: functional effects; milk oligosaccharides; human milk; effects human ... See more keywords