First Reports of Effects of Insulin, Human-like Insulin Receptors and Adapter Proteins in Acanthamoeba castellanii
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DOI: 10.1038/s41598-020-63435-4
Abstract: The insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1-R) play key roles in growth, regulation of nutrient metabolism and carbohydrate homeostasis. Insulin-like molecules in prokaryotes and other early life have been reported. However,… read more here.
Keywords: insulin; growth; acanthamoeba spp; homology modelling ... See more keywords
Nutritional and developmental programming effects of insulin
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DOI: 10.1111/jne.12933
Abstract: The discovery of insulin in 1921 was a major breakthrough in medicine and for therapy in patients with diabetes. The dramatic rise in the prevalence of overweight and obesity has been tightly linked to an… read more here.
Keywords: medicine; nutritional developmental; programming effects; obesity ... See more keywords
Genetic and Physiological Effects of Insulin on Human Urate Homeostasis
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DOI: 10.3389/fphys.2021.713710
Abstract: Insulin and hyperinsulinemia reduce renal fractional excretion of urate (FeU) and play a key role in the genesis of hyperuricemia and gout, via uncharacterized mechanisms. To explore this association further we studied the effects of… read more here.
Keywords: insulin; urate transporters; expression; effects insulin ... See more keywords