Effects of ketamine‐induced H3K9 hypoacetylation during pregnancy on cardiogenesis of mouse offspring
Sign Up to like & getrecommendations! Published in 2023 at "Birth Defects Research"
DOI: 10.1002/bdr2.2168
Abstract: Prenatal exposure to adverse factors can cause congenital heart defects. Ketamine, a widely used anesthetic drug, produces several adverse reactions such as tachycardia, hypertension, and laryngospasm, especially in pediatric patients. This study aimed to detect… read more here.
Keywords: cardiogenesis mouse; pregnancy cardiogenesis; effects ketamine; mouse offspring ... See more keywords
Effects of ketamine on brain function during response inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5081-7
Abstract: IntroductionThe uncompetitive N-methyl-D-aspartate (NMDA) receptor (NMDAR) antagonist ketamine has been proposed to model symptoms of psychosis. Inhibitory deficits in the schizophrenia spectrum have been reliably reported using the antisaccade task. Interestingly, although similar antisaccade deficits… read more here.
Keywords: effects ketamine; ketamine; ketamine brain; brain function ... See more keywords
Mediation of the behavioral effects of ketamine and (2R,6R)-hydroxynorketamine in mice by kappa opioid receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Psychopharmacology"
DOI: 10.1007/s00213-022-06118-4
Abstract: Emerging evidence has implicated the endogenous opioid system in mediating ketamine's antidepressant activity in subjects with major depressive disorder. To date, mu opioid receptors have been suggested as the primary opioid receptor of interest. However,… read more here.
Keywords: effects ketamine; kappa opioid; opioid receptors; swim test ... See more keywords
Acute effects of ketamine on the pregenual anterior cingulate: linking spontaneous activation, functional connectivity, and glutamate metabolism
Sign Up to like & getrecommendations! Published in 2022 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-021-01377-2
Abstract: Ketamine exerts its rapid antidepressant effects via modulation of the glutamatergic system. While numerous imaging studies have investigated the effects of ketamine on a functional macroscopic brain level, it remains unclear how altered glutamate metabolism… read more here.
Keywords: activation; glutamate; functional connectivity; effects ketamine ... See more keywords
Effects of Ketamine and Midazolam on Simultaneous EEG/fMRI Data During Working Memory Processes.
Sign Up to like & getrecommendations! Published in 2021 at "Brain topography"
DOI: 10.1007/s10548-021-00876-8
Abstract: Reliable measures of cognitive brain activity from functional neuroimaging techniques may provide early indications of efficacy in clinical trials. Functional magnetic resonance imaging and electroencephalography provide complementary spatiotemporal information and simultaneous recording of these two… read more here.
Keywords: theta; effects ketamine; bold signal; midazolam simultaneous ... See more keywords
Mechanistic Target of Rapamycin–Independent Antidepressant Effects of (R)-Ketamine in a Social Defeat Stress Model
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.05.016
Abstract: BACKGROUND The role of the mechanistic target of rapamycin (mTOR) signaling in the antidepressant effects of ketamine is controversial. In addition to mTOR, extracellular signal-regulated kinase (ERK) is a key signaling molecule in prominent pathways… read more here.
Keywords: effects ketamine; model; ketamine ketamine; mtor ... See more keywords
Neurobiology of the Rapid-Acting Antidepressant Effects of Ketamine: Impact and Opportunities
Sign Up to like & getrecommendations! Published in 2021 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2020.12.006
Abstract: The discovery of the rapid-acting antidepressant effects of ketamine has 1) led to a paradigm shift in our perception of what is possible in treating severe depression; 2) spurred a wave of basic, translation, and… read more here.
Keywords: rapid acting; pathology; effects ketamine; neurobiology ... See more keywords
Comparative effects of (S)-ketamine and racemic (R/S)-ketamine on psychopathology, state of consciousness and neurocognitive performance in healthy volunteers
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2021.01.005
Abstract: Ketamine and its (S)-enantiomer show distinct psychological effects that are investigated in psychiatric research. Its antidepressant activity may depend on the extent and quality of these psychological effects which may greatly differ between the enantiomers.… read more here.
Keywords: ketamine; effects ketamine; ketamine ketamine; compared ketamine ... See more keywords
Ketamine increases vmPFC activity: Effects of (R)- and (S)-stereoisomers and (2R,6R)-hydroxynorketamine metabolite
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.107947
Abstract: Ketamine, an NMDA receptor antagonist and fast acting antidepressant, produces a rapid burst of glutamate in the ventral medial prefrontal cortex (mPFC). Preclinical studies have demonstrated that pyramidal cell activity in the vmPFC is necessary… read more here.
Keywords: gcamp6f; nmda receptor; ketamine; effects ketamine ... See more keywords
Distinct cognitive and discriminative stimulus effects of ketamine enantiomers in rats
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2020.173011
Abstract: Although (S)-ketamine was approved for use in treatment-resistant patients in 2019, new preclinical findings suggest that (R)-ketamine might produce better efficacy and tolerability relative to (S)-ketamine. Here we evaluated the effects of (R)-, (S)-, and… read more here.
Keywords: ketamine; stimulus effects; discriminative stimulus; effects ketamine ... See more keywords
The effects of ketamine on dopaminergic function: meta-analysis and review of the implications for neuropsychiatric disorders
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/mp.2017.190
Abstract: Ketamine is a non-competitive antagonist at the N-methyl-d-aspartate receptor. It has recently been found to have antidepressant effects and is a drug of abuse, suggesting it may have dopaminergic effects. To examine the effect of… read more here.
Keywords: ketamine administration; analysis; dopamine; effects ketamine ... See more keywords