Immunometabolic effects of lactate on humoral immunity in healthy individuals of different ages
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51207-x
Abstract: Aging is characterized by chronic systemic inflammation and metabolic changes. We compare the metabolic status of B cells from young and elderly donors and found that aging is associated with higher oxygen consumption rates, and… read more here.
Keywords: cells young; different ages; effects lactate; metabolic status ... See more keywords
Cardiovascular effects of lactate infusion in cardiogenic shock complicating acute myocardial infarction
Sign Up to like & getrecommendations! Published in 2025 at "European Heart Journal: Acute Cardiovascular Care"
DOI: 10.1093/ehjacc/zuaf044.160
Abstract: Cardiogenic shock complicating myocardial infarction (AMI-CS) is charactirized by reduced cardiac output (CO), poor end-organ perfusion, and high mortality. Current medical therapies have not significantly improved survival rates. Lactate, though often considered a toxic byproduct… read more here.
Keywords: heart; infusion; effects lactate; lactate infusion ... See more keywords
Effects of lactate concentration on T‐cell phenotype and mitochondrial respiration
Sign Up to like & getrecommendations! Published in 2025 at "Physiological Reports"
DOI: 10.14814/phy2.70450
Abstract: Lactate is a critical regulator of cellular processes and immune signaling, and we hypothesize that exercise‐induced elevations in lactate help activate immune cells in response to vigorous exercise. Despite its importance, the impact of lactate… read more here.
Keywords: respiration; mitochondrial respiration; cell; effects lactate ... See more keywords
Lactate-related metabolic reprogramming and immune regulation in colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1089918
Abstract: Changes in cellular metabolism involving fuel sources are well-known mechanisms of cancer cell differentiation in the context of carcinogenesis. Metabolic reprogramming is regulated by oncogenic signaling and transcriptional networks and has been identified as an… read more here.
Keywords: metabolism; tumor microenvironment; metabolic reprogramming; colorectal cancer ... See more keywords
In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02564
Abstract: Lactate, the end product of anaerobic glycolysis, is produced in high amounts by innate immune cells during inflammatory activation. Although immunomodulating effects of lactate have been reported, evidence from human studies is scarce. Here we… read more here.
Keywords: immune; effects lactate; lactate metabolism; metabolism ... See more keywords
Effects of Lactate on One Class of Group III (CT3) Muscle Afferents
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.00215
Abstract: A class of Group III muscle afferent neurons has branching sensory terminals in the connective tissue between layers of mouse abdominal muscles (“CT3 muscle afferents”). These sensory endings are both mechanosensitive and metabosensitive. In the… read more here.
Keywords: effects lactate; muscle; group iii; class group ... See more keywords