Neuroprotective effects of leptin on cerebral ischemia through JAK2/STAT3/PGC-1-mediated mitochondrial function modulation
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DOI: 10.1016/j.brainresbull.2020.01.002
Abstract: Neuroprotective effects of leptin have been shown in mouse model of cerebral ischemia/reperfusion injury and primary cortical neuronal culture with oxygen-glucose deprivation (OGD), while the underlying mechanisms are less understood. In the present study, we… read more here.
Keywords: jak2 stat3; effects leptin; neuroprotective effects; stat3 ... See more keywords
Decreased sensitivity to the anorectic effects of leptin in mice that lack a Pomc-specific neural enhancer
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DOI: 10.1371/journal.pone.0244793
Abstract: Enhancer redundancy has been postulated to provide a buffer for gene expression against genetic and environmental perturbations. While work in Drosophila has identified functionally overlapping enhancers, work in mammalian models has been limited. Recently, we… read more here.
Keywords: enhancer; effects leptin; pomc; anorectic effects ... See more keywords
The Effects of Leptin on Glial Cells in Neurological Diseases
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DOI: 10.3389/fnins.2019.00828
Abstract: It is known that various endocrine modulators, including leptin and ghrelin, have neuroprotective roles in neurological diseases. Leptin is a hormone produced by adipocytes and was originally identified as a gene related to obesity in… read more here.
Keywords: effects leptin; glial cells; leptin; neurological diseases ... See more keywords
The Acute Effects of Leptin on the Contractility of Isolated Rat Atrial and Ventricular Cardiomyocytes
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DOI: 10.3390/ijms23158356
Abstract: Leptin is a pleiotropic peptide playing an important role in the regulation of cardiac functions. It is not clear whether leptin directly modulates the mechanical function of atrial cardiomyocytes. We compared the acute effects of… read more here.
Keywords: ventricular cardiomyocytes; rat atrial; effects leptin; acute effects ... See more keywords