Cartilage-protective effects of lopinavir/ritonavir: in vitro and in silico exploration of the HIF-1α/SOX9/IL-1β pathway
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DOI: 10.1186/s13018-025-06068-5
Abstract: This study aimed to investigate the effects of Lopinavir/Ritonavir (Lop/r) on chondrocyte structure and extracellular matrix (ECM) integrity, as well as its impact on key proteins involved in anabolic and catabolic pathways, using both in… read more here.
Keywords: lopinavir ritonavir; hif sox9; effects lopinavir; vitro silico ... See more keywords
High dietary fat modulates neurobehavioural but not oxidative and neurochemical effects of lopinavir/ritonavir in mice.
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DOI: 10.2174/1389201020666191011144930
Abstract: BACKGROUND We assessed the effects of lopinavir/ritonavir on neurobehaviour, neurochemistry and oxidative status in healthy mice. Also, the impact of high dietary fat on the parameters measured was also assessed. METHODS Mice were randomly-assigned into… read more here.
Keywords: fat diet; effects lopinavir; fat; high dietary ... See more keywords