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   Articles with "effects metformin" as a keyword



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Effects of Metformin on the virus/host cell crosstalk in human papillomavirus‐positive cancer cells

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recommendations! Published in 2021 at "International Journal of Cancer"

DOI: 10.1002/ijc.33594

Abstract: Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The viral E6/E7 oncogenes maintain the malignant growth of HPV‐positive cancer cells. Targeted E6/E7 inhibition results in efficient induction of cellular senescence, which could be… read more here.

Keywords: positive cancer; senescence; cancer cells; cancer ... See more keywords

Concentration‐dependent metabolic effects of metformin in healthy and Fanconi anemia lymphoblast cells

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recommendations! Published in 2018 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.26085

Abstract: Metformin (MET) is the drug of choice for patients with type 2 diabetes and has been proposed for use in cancer therapy and for treating other metabolic diseases. More than 14,000 studies have been published… read more here.

Keywords: fanconi anemia; dependent metabolic; concentration dependent; concentration ... See more keywords

Pleiotropic Effects of Metformin on the Chemotherapy Response of HPV‐Positive Cancer Cells

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recommendations! Published in 2025 at "Journal of Medical Virology"

DOI: 10.1002/jmv.70434

Abstract: Improved treatment strategies for HPV‐positive cancers are urgently required. The viral E6/E7 oncoproteins are essential for the proliferation of HPV‐positive cancer cells and considered attractive therapeutic targets. Metformin is proposed to be repurposed for cancer… read more here.

Keywords: cancer; cancer cells; effects metformin; positive cancer ... See more keywords

Palliative effects of metformin on testicular damage induced by triptolide in male rats.

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recommendations! Published in 2021 at "Ecotoxicology and environmental safety"

DOI: 10.1016/j.ecoenv.2021.112536

Abstract: As a widely existing traditional Chinese medicine component, TP (triptolide) has serious reproductive toxicity which causes severe damage to the reproductive system and limits its application prospect. TP and MET (metformin) have shown great potential… read more here.

Keywords: effects metformin; damage; reproductive toxicity; metformin testicular ... See more keywords

Anti-diabetic and anti-aging effects of metformin on metabolic and molecular parameters in diabetic aging female rats

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.04.351

Abstract: Objective The objective of this study was to investigate beneficial effects of metformin on membrane bound enzymes (Na+ K+ ATPse,) and antioxidant enzymes (superoxidase dismutase), lipid peroxidation, expression of glucose transporter(Glut4), DNA degradation in brain… read more here.

Keywords: diabetic aging; aging female; study; membrane ... See more keywords

Metabolic switching in the hypoglycemic and antitumor effects of metformin on high glucose induced HepG2 cells

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recommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"

DOI: 10.1016/j.jpba.2018.04.029

Abstract: HighlightsGlucose metabolic imbalance were observed in 25 mM glucose induced HepG2 cells.ASCA was used to study hypoglycemic and antitumor effects of metformin on IR‐HepG2.Five metabolites play vital roles in hypoglycemic and antitumor effects of metformin.… read more here.

Keywords: antitumor effects; induced hepg2; hypoglycemic antitumor; hepg2 cells ... See more keywords

Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with adenylyl cyclase activating signals

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recommendations! Published in 2018 at "Molecular and Cellular Endocrinology"

DOI: 10.1016/j.mce.2017.09.030

Abstract: For a few years we have been investigating AMP-activated protein kinase (AMPK) as a target for drug therapy of GH-secreting pituitary adenomas. Aim of this study was to investigate the direct effects of metformin, which… read more here.

Keywords: cell; pituitary adenoma; cell growth; growth ... See more keywords
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Metformin: A review of its therapeutic efficacy and adverse effects

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recommendations! Published in 2020 at "Obesity Medicine"

DOI: 10.1016/j.obmed.2020.100186

Abstract: Abstract Managing obesity is a substantial aspect worldwide as well as in diabetic patients. Most oral antidiabetic medications increase body weight. Metformin, the most recommended first-line oral antidiabetic is also considered a weight management agent;… read more here.

Keywords: metformin; therapeutic efficacy; review therapeutic; adverse effects ... See more keywords

Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis.

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recommendations! Published in 2017 at "Clinical science"

DOI: 10.1042/cs20160438

Abstract: Studies suggest that metformin, widely used for treating Type 2 diabetes, possesses innate antineoplastic properties. For metabolic syndrome patients with hepatocellular carcinoma (HCC), metformin may provide antitumoral effects. We evaluated the impact of metformin on tumour… read more here.

Keywords: strong antineoplastic; preclinical models; mice; hfd mice ... See more keywords

Metabolic and Metabolomic Effects of Metformin in Murine Model of Pulmonary Adenoma Formation

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recommendations! Published in 2023 at "Nutrition and Cancer"

DOI: 10.1080/01635581.2023.2165692

Abstract: Abstract Epidemiologic studies of diabetic patients treated with metformin identified significantly lower incidences of cancer. From this, there is growing interest in the use of metformin to treat and prevent cancer. Studies have investigated chemopreventive… read more here.

Keywords: metabolomic effects; metformin murine; metabolic metabolomic; effects metformin ... See more keywords

The ameliorative effects of metformin and taurine against thioacetamide hepatotoxicity in rats.

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recommendations! Published in 2025 at "Toxicology research"

DOI: 10.1093/toxres/tfaf076

Abstract: The main objective of this research was to investigate the therapeutic, anti-inflammatory, and histological effects of metformin and taurine, both alone and in combination, against thioacetamide (TAA)-induced hepatotoxicity in rats. The study included forty adult… read more here.

Keywords: hepatotoxicity rats; effects metformin; group; rats received ... See more keywords