Effects of Metformin on the virus/host cell crosstalk in human papillomavirus‐positive cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Cancer"
DOI: 10.1002/ijc.33594
Abstract: Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The viral E6/E7 oncogenes maintain the malignant growth of HPV‐positive cancer cells. Targeted E6/E7 inhibition results in efficient induction of cellular senescence, which could be… read more here.
Keywords: positive cancer; senescence; cancer cells; cancer ... See more keywords
Concentration‐dependent metabolic effects of metformin in healthy and Fanconi anemia lymphoblast cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26085
Abstract: Metformin (MET) is the drug of choice for patients with type 2 diabetes and has been proposed for use in cancer therapy and for treating other metabolic diseases. More than 14,000 studies have been published… read more here.
Keywords: fanconi anemia; dependent metabolic; concentration dependent; concentration ... See more keywords
Palliative effects of metformin on testicular damage induced by triptolide in male rats.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112536
Abstract: As a widely existing traditional Chinese medicine component, TP (triptolide) has serious reproductive toxicity which causes severe damage to the reproductive system and limits its application prospect. TP and MET (metformin) have shown great potential… read more here.
Keywords: effects metformin; damage; reproductive toxicity; metformin testicular ... See more keywords
Anti-diabetic and anti-aging effects of metformin on metabolic and molecular parameters in diabetic aging female rats
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.351
Abstract: Objective The objective of this study was to investigate beneficial effects of metformin on membrane bound enzymes (Na+ K+ ATPse,) and antioxidant enzymes (superoxidase dismutase), lipid peroxidation, expression of glucose transporter(Glut4), DNA degradation in brain… read more here.
Keywords: diabetic aging; aging female; study; membrane ... See more keywords
Metabolic switching in the hypoglycemic and antitumor effects of metformin on high glucose induced HepG2 cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.04.029
Abstract: HighlightsGlucose metabolic imbalance were observed in 25 mM glucose induced HepG2 cells.ASCA was used to study hypoglycemic and antitumor effects of metformin on IR‐HepG2.Five metabolites play vital roles in hypoglycemic and antitumor effects of metformin.… read more here.
Keywords: antitumor effects; induced hepg2; hypoglycemic antitumor; hepg2 cells ... See more keywords
Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with adenylyl cyclase activating signals
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.09.030
Abstract: For a few years we have been investigating AMP-activated protein kinase (AMPK) as a target for drug therapy of GH-secreting pituitary adenomas. Aim of this study was to investigate the direct effects of metformin, which… read more here.
Keywords: cell; pituitary adenoma; cell growth; growth ... See more keywords
Metformin: A review of its therapeutic efficacy and adverse effects
Sign Up to like & getrecommendations! Published in 2020 at "Obesity Medicine"
DOI: 10.1016/j.obmed.2020.100186
Abstract: Abstract Managing obesity is a substantial aspect worldwide as well as in diabetic patients. Most oral antidiabetic medications increase body weight. Metformin, the most recommended first-line oral antidiabetic is also considered a weight management agent;… read more here.
Keywords: metformin; therapeutic efficacy; review therapeutic; adverse effects ... See more keywords
Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis.
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DOI: 10.1042/cs20160438
Abstract: Studies suggest that metformin, widely used for treating Type 2 diabetes, possesses innate antineoplastic properties. For metabolic syndrome patients with hepatocellular carcinoma (HCC), metformin may provide antitumoral effects. We evaluated the impact of metformin on tumour… read more here.
Keywords: strong antineoplastic; preclinical models; mice; hfd mice ... See more keywords
Metabolic and Metabolomic Effects of Metformin in Murine Model of Pulmonary Adenoma Formation
Sign Up to like & getrecommendations! Published in 2023 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2023.2165692
Abstract: Abstract Epidemiologic studies of diabetic patients treated with metformin identified significantly lower incidences of cancer. From this, there is growing interest in the use of metformin to treat and prevent cancer. Studies have investigated chemopreventive… read more here.
Keywords: metabolomic effects; metformin murine; metabolic metabolomic; effects metformin ... See more keywords
Metformin, lipids and atherosclerosis prevention
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Lipidology"
DOI: 10.1097/mol.0000000000000532
Abstract: Purpose of review We provide an overview of recent publications that extend clinically relevant knowledge relating to metformin's effects on lipids and atherosclerotic vascular disease and/or provide insights into the drug's mechanisms of action on… read more here.
Keywords: atherosclerosis prevention; vascular disease; disease; lipids atherosclerosis ... See more keywords
Differential effects of metformin‐mediated BSEP repression on pravastatin and bile acid pharmacokinetics in humans: A randomized controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13375
Abstract: Metformin has been shown to repress transcription of the bile salt export pump (BSEP) in human primary hepatocytes. The primary objective of this study was to assess the effect of oral metformin on the human… read more here.
Keywords: cdca; metformin mediated; mediated bsep; differential effects ... See more keywords