Deciphering the Molecular Effects of Mutations on ATRX Cause ATRX Syndrome: A Molecular Dynamics Study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25984
Abstract: α‐thalassemia mental retardation X‐linked (ATRX) syndrome is caused by the dysfunction of ATRFfigX protein. The present study explored the structural consequences influenced by two observed mutations V194I and C220R on ADD domain of ATRX protein… read more here.
Keywords: deciphering molecular; molecular dynamics; atrx syndrome; add domain ... See more keywords
BayeStab: Predicting effects of mutations on protein stability with uncertainty quantification
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4467
Abstract: Predicting protein thermostability change upon mutation is crucial for understanding diseases and designing therapeutics. However, accurately estimating Gibbs free energy change of the protein remained a challenge. Some methods struggle to generalize on examples with… read more here.
Keywords: bayestab predicting; uncertainty; predicting effects; bayestab ... See more keywords
Deep generative models of genetic variation capture the effects of mutations
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DOI: 10.1038/s41592-018-0138-4
Abstract: The functions of proteins and RNAs are defined by the collective interactions of many residues, and yet most statistical models of biological sequences consider sites nearly independently. Recent approaches have demonstrated benefits of including interactions… read more here.
Keywords: models genetic; effects mutations; generative models; capture ... See more keywords
Epistatic drift causes gradual decay of predictability in protein evolution
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DOI: 10.1126/science.abn6895
Abstract: Epistatic interactions can make the outcomes of evolution unpredictable, but no comprehensive data are available on the extent and temporal dynamics of changes in the effects of mutations as protein sequences evolve. Here, we use… read more here.
Keywords: drift causes; evolution epistatic; epistatic interactions; epistatic drift ... See more keywords