Prediction of ligand effects in platinum-amyloid-β coordination.
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DOI: 10.1016/j.jinorgbio.2017.05.003
Abstract: Ligand field molecular mechanics (LFMM) and semi-empirical Parametric Model 7 (PM7) methods are applied to a series of six PtII-Ligand systems binding to the N-terminal domain of the amyloid-β (Aβ) peptide. Molecular dynamics using a… read more here.
Keywords: coordination; peptide; effects platinum; prediction ligand ... See more keywords
The side effects of platinum-based chemotherapy drugs: a review for chemists.
Sign Up to like & getrecommendations! Published in 2018 at "Dalton transactions"
DOI: 10.1039/c8dt00838h
Abstract: The platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects (also referred to as adverse… read more here.
Keywords: effects platinum; platinum based; based chemotherapy; side ... See more keywords
The effects of platinum(IV) complexes on Aβ1-42 aggregation: a synergistic inhibition upon axial coordination.
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DOI: 10.1039/d5dt00691k
Abstract: Among novel metallodrugs, Pt(IV) complexes have been receiving increasing attention as alternatives to Pt(II) analogues since they exhibit superior kinetic inertness and, hence, fewer undesirable reactions. Pt(IV) complexes have been designed as prodrugs with mechanisms… read more here.
Keywords: aggregation synergistic; synergistic inhibition; effects platinum; complexes aggregation ... See more keywords