EFFECTS OF SGLT2 INHIBITORS ON STROKE IN TYPE 2 DIABETES ACCORDING TO BASELINE KIDNEY FUNCTION
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(20)30848-2
Abstract: Baseline kidney function appeared to modify the effects of the SGLT2 inhibitor canagliflozin compared to placebo on stroke in the CANVAS Program. We extracted data from the EMPA-REG OUTCOME, DECLARE-TIMI 58 and CREDENCE trials to… read more here.
Keywords: baseline kidney; kidney function; effects sglt2;
Mechanisms of protective effects of SGLT2 inhibitors in cardiovascular disease and renal dysfunction.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026619666190828161409
Abstract: Type 2 diabetes mellitus is one of the most common form of the disease worldwide. Hyperglycemia and insulin resistance play key roles in type 2 diabetes mellitus. Renal glucose reabsorption is an essential feature in… read more here.
Keywords: sglt2 inhibitors; renal dysfunction; disease; type diabetes ... See more keywords
Effects of the SGLT2 Inhibition on Cardiac Remodeling in Streptozotocin-Induced Diabetic Rats, a Model of Type 1 Diabetes Mellitus
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DOI: 10.3390/antiox11050982
Abstract: Clinical trials have shown that sodium glucose co-transporter 2 (SGLT2) inhibitors improve clinical outcomes in diabetes mellitus (DM) patients. As most studies were performed in Type 2 DM, the cardiovascular effects of SGLT2 inhibition still… read more here.
Keywords: effects sglt2; dapa; sglt2 inhibition; model type ... See more keywords
Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class
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DOI: 10.3390/ijms22063062
Abstract: Sodium-glucose co-transporter 2 (SGLT2) inhibitors facilitate urine glucose excretion by reducing glucose reabsorption, leading to ameliorate glycemic control. While the main characteristics of type 2 diabetes mellitus are insufficient insulin secretion and insulin resistance, SGLT2… read more here.
Keywords: sglt2 inhibitors; insulin; inhibitors pearls; pleiotropic effects ... See more keywords