EFFECTS OF SGLT2 INHIBITORS ON STROKE IN TYPE 2 DIABETES ACCORDING TO BASELINE KIDNEY FUNCTION
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(20)30848-2
Abstract: Baseline kidney function appeared to modify the effects of the SGLT2 inhibitor canagliflozin compared to placebo on stroke in the CANVAS Program. We extracted data from the EMPA-REG OUTCOME, DECLARE-TIMI 58 and CREDENCE trials to… read more here.
Keywords: baseline kidney; kidney function; effects sglt2;
#2495 Renal and peritoneal protective effects of SGLT2 Inhibitors in incident peritoneal dialysis (PD) patients
Sign Up to like & getrecommendations! Published in 2024 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfae069.934
Abstract: The renoprotective effect of SGLT2 inhibitors has been evaluated in several large studies, but renal function of the subject is defined as eGFR≥20-30 mL/min/1.73 m2 or higher in most studies. On the other hand, SGLT2… read more here.
Keywords: protective effects; group; sglt2 inhibitors; renal peritoneal ... See more keywords
Antihypertensive Effects of SGLT2-Inhibitors: Considerations for Clinical Practice.
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DOI: 10.2174/0115701611274645231208102130
Abstract: read more here.
Keywords: antihypertensive effects; sglt2 inhibitors; clinical practice; effects sglt2 ... See more keywords
Mechanisms of protective effects of SGLT2 inhibitors in cardiovascular disease and renal dysfunction.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026619666190828161409
Abstract: Type 2 diabetes mellitus is one of the most common form of the disease worldwide. Hyperglycemia and insulin resistance play key roles in type 2 diabetes mellitus. Renal glucose reabsorption is an essential feature in… read more here.
Keywords: sglt2 inhibitors; renal dysfunction; disease; type diabetes ... See more keywords
GRP78 contributes to the beneficial effects of SGLT2 inhibitor on proximal tubular cells in DKD.
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DOI: 10.2337/db23-0581
Abstract: Beneficial effects of SGLT2 inhibitors on kidney function are well-known; however, their molecular mechanisms are not fully understood. We focused on 78 kDa glucose-regulated protein (GRP78) and its interaction with SGLT2 and Integrin ß1 beyond… read more here.
Keywords: beneficial effects; integrin; tubular cells; grp78 ... See more keywords
Effects of the SGLT2 Inhibition on Cardiac Remodeling in Streptozotocin-Induced Diabetic Rats, a Model of Type 1 Diabetes Mellitus
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DOI: 10.3390/antiox11050982
Abstract: Clinical trials have shown that sodium glucose co-transporter 2 (SGLT2) inhibitors improve clinical outcomes in diabetes mellitus (DM) patients. As most studies were performed in Type 2 DM, the cardiovascular effects of SGLT2 inhibition still… read more here.
Keywords: effects sglt2; dapa; sglt2 inhibition; model type ... See more keywords
Hemodynamic Effects of SGLT2 Inhibitors in Patients with and Without Diabetes Mellitus—A Narrative Review
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DOI: 10.3390/healthcare12232464
Abstract: Background: The current review aims to present the beneficial effects of SGLT2 inhibitors (dapagliflozin and empagliflozin) on several hemodynamic parameters such as blood pressure, filtration pressure at the level of the glomerular capillaries, and the… read more here.
Keywords: pressure; review; heart; hemodynamic effects ... See more keywords
Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class
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DOI: 10.3390/ijms22063062
Abstract: Sodium-glucose co-transporter 2 (SGLT2) inhibitors facilitate urine glucose excretion by reducing glucose reabsorption, leading to ameliorate glycemic control. While the main characteristics of type 2 diabetes mellitus are insufficient insulin secretion and insulin resistance, SGLT2… read more here.
Keywords: sglt2 inhibitors; insulin; inhibitors pearls; pleiotropic effects ... See more keywords