Hepatic transcriptional effects of simvastatin and the possible impact on COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2021.06.428
Abstract: Background and Aims: Recent reports show an association between statins therapy and reduction in 28-day all-cause mortality among Coronavirus disease 2019 (COVID-19) patients. This association is poorly understood mechanistically. Hence, we investigated whether simvastatin regulates… read more here.
Keywords: transcriptional effects; simvastatin possible; possible impact; hepatic transcriptional ... See more keywords
Ilexgenin A enhances the effects of simvastatin on non-alcoholic fatty liver disease without changes in simvastatin pharmacokinetics.
Sign Up to like & getrecommendations! Published in 2018 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(18)30077-3
Abstract: Cardiovascular disease (CVD) is the most common cause of death in patients with non-alcoholic fatty liver disease (NAFLD). New therapeutic strategies which have the potential for slowing down the evolution of NAFLD and reducing CVD-related… read more here.
Keywords: alcoholic fatty; fatty liver; non alcoholic; disease ... See more keywords
Effects of Simvastatin on Fetal Cardiac Impairment in the Diaphragmatic Experimental Hernia Model
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DOI: 10.1159/000490144
Abstract: Background: Statins and sildenafil have been shown to exert beneficial effects in cardiac injury. We hypothesized that antenatal maternal administration of simvastatin and/or sildenafil might also promote benefits in cardiac remodeling of congenital diaphragmatic hernia… read more here.
Keywords: hernia; compared controls; simvastatin; simvastatin fetal ... See more keywords
Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling
Sign Up to like & getrecommendations! Published in 2021 at "Theranostics"
DOI: 10.7150/thno.48153
Abstract: Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) are the most abundant non-myocyte cells in adult mouse heart. Simvastatin, a… read more here.
Keywords: inhibition; foxp1; cardiac remodeling; maladaptive cardiac ... See more keywords