Side effects of statins-from pathophysiology and epidemiology to diagnostic and therapeutic implications.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac020
Abstract: Treatment with statins, inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase, has proven beneficial preventive effects on cardiovascular events. However, discontinuation due to intolerance and nonadherence remain two of the major gaps in both primary and secondary prevention. This… read more here.
Keywords: side effects; effects statins; risk; statins pathophysiology ... See more keywords
Comparison of pleiotropic effects of statins vs fibrates on laboratory parameters in patients with dyslipidemia
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000023427
Abstract: Abstract Differences in the mechanism of action and potential pleiotropic effects between statins and fibrates would potentially drive a different effect on various laboratory parameters, but this remains controversial because of a paucity of reports… read more here.
Keywords: statin users; statins fibrates; fibrate users; matched pairs ... See more keywords
Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review
Sign Up to like & getrecommendations! Published in 2023 at "Iranian Journal of Medical Sciences"
DOI: 10.30476/ijms.2021.91645.2289
Abstract: Among the many types of central nervous system (CNS) disorders, seizures and epilepsy severely affect the quality of life and routine daily activity of the sufferers. We aimed to review research studies that investigated the… read more here.
Keywords: effect; review; seizures epilepsy; effects statins ... See more keywords
Statins and cognition: Modifying factors and possible underlying mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.968039
Abstract: Statins are a class of widely prescribed drugs used to reduce low-density lipoprotein cholesterol (LDL-C) and important to prevent cardiovascular diseases (CVD). Most statin users are older adults with CVD, who are also at high… read more here.
Keywords: factors possible; cognition modifying; modifying factors; underlying mechanisms ... See more keywords
Statins in Depression: An Evidence-Based Overview of Mechanisms and Clinical Studies
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2021.702617
Abstract: Background: Depression is a leading cause of disability, burdened by high levels of non-response to conventional antidepressants. Novel therapeutic strategies targeting non-monoaminergic pathways are sorely needed. The widely available and safe statins have several putative… read more here.
Keywords: depression; clinical studies; effects statins; statins depression ... See more keywords
Differential Effects of Statins on Inflammatory Interleukin-8 and Antimicrobial Peptide Human Β-Defensin 2 Responses in Salmonella-Infected Intestinal Epithelial Cells
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19061650
Abstract: Alternative therapies are needed to reduce the use of antibiotics and incidence of drug-resistant Salmonellosis. Previous studies have revealed important roles of statins in regulating innate immunity. Therefore, we investigated the effects of statins on… read more here.
Keywords: salmonella infected; intestinal epithelial; effects statins; infected intestinal ... See more keywords
Regulatory Effects of Statins on SIRT1 and Other Sirtuins in Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12050760
Abstract: Adverse cardiovascular disease (CVD) outcomes, such as sudden cardiac death, acute myocardial infarction, and stroke, are often catastrophic. Statins are frequently used to attenuate the risk of CVD-associated morbidity and mortality through their impact on… read more here.
Keywords: sirt1 sirtuins; regulatory effects; sirtuins cardiovascular; cardiovascular diseases ... See more keywords
The Effects of Statins on Neurotransmission and Their Neuroprotective Role in Neurological and Psychiatric Disorders
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26102838
Abstract: Statins are among the most widely used drug classes in the world. Apart from their basic mechanism of action, which is lowering cholesterol levels, many pleiotropic effects have been described so far, such as anti-inflammatory… read more here.
Keywords: effects statins; pleiotropic effects; statins neurotransmission; neurological psychiatric ... See more keywords