The Effects of N-terminal Mutations on β-amyloid Peptide Aggregation and Toxicity
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.03.014
Abstract: Human amyloid β1-42 (hAβ1-42) peptides are known to self-aggregate into oligomers that contribute to the degeneration of neurons and development of Alzheimer's disease (AD) pathology. Unlike humans, rodents do not develop AD, possibly due to… read more here.
Keywords: effects terminal; mutations amyloid; aggregation toxicity; toxicity ... See more keywords
Effects of C-Terminal B-Chain Modifications in a Relaxin 3 Agonist Analogue.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00456
Abstract: The receptor for the neuropeptide relaxin 3, relaxin family peptide 3 (RXFP3) receptor, is an attractive pharmacological target for the control of eating, addictive, and psychiatric behaviors. Several structure-activity relationship studies on both human relaxin… read more here.
Keywords: chain; effects terminal; terminal chain; relaxin agonist ... See more keywords