Differential Effects of Ticagrelor With or Without Aspirin on Platelet Reactivity and Coagulation Activation: A Randomized Trial in Healthy Volunteers
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1616
Abstract: Dual antiplatelet therapy (DAPT) is standard in acute coronary heart disease but confers a bleeding risk. To compare the effects of ticagrelor‐monotherapy with ticagrelor‐based DAPT on hemostatic system activation, we conducted a randomized controlled trial… read more here.
Keywords: trial; ticagrelor; ticagrelor based; effects ticagrelor ... See more keywords
Effects of Ticagrelor, Prasugrel, or Clopidogrel at Steady State on Endothelial Function.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.01.027
Abstract: Ticagrelor is a nonthienopyridine direct and reversible P2Y12 platelet receptor antagonist, and unlike prasugrel or clopidogrel inhibits, at least partially, the sodium-independent equilibrative nucleoside transporter 1 [(1)][1]. This ticagrelor-mediated off-target effect has potential to improve read more here.
Keywords: prasugrel; clopidogrel steady; prasugrel clopidogrel; ticagrelor prasugrel ... See more keywords
Effects of ticagrelor in a mouse model of ischemic stroke
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DOI: 10.1038/s41598-017-12205-w
Abstract: Ticagrelor is a direct acting and reversibly binding P2Y12 antagonist approved for the prevention of thromboembolic events. Its potential benefits in ischemic stroke have not been investigated sufficiently. Mice were subjected to 2 hours of transient… read more here.
Keywords: ischemic stroke; ticagrelor; effects ticagrelor; mouse model ... See more keywords
Effects of ticagrelor pretreatment on electrophysiological properties of stellate ganglion neurons following myocardial infarction
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13385
Abstract: Higher sympathetic activity predisposes to malignant ventricular arrhythmias in the context of myocardial infarction (MI). This is, in part, mediated by the electrical activity of the stellate ganglion (SG). The aim of this study is… read more here.
Keywords: myocardial infarction; pretreatment electrophysiological; effects ticagrelor; electrophysiological properties ... See more keywords
Effects of Ticagrelor on Myocardial Infarct Size
Sign Up to like & getrecommendations! Published in 2017 at "Korean Circulation Journal"
DOI: 10.4070/kcj.2017.0161
Abstract: Ticagrelor (Brilinta; AstraZeneca Pharmaceuticals LP, Wilmington, DE, USA) is a direct acting, reversible, oral P2Y12 inhibitor.1) In the PLATelet inhibition and patient Outcomes (PLATO) study, compared to clopidogrel (Plavix; Bristol-Myers Squibb/Sanofi Pharmaceuticals, Bridgewater, NJ, USA),… read more here.
Keywords: effects ticagrelor; ticagrelor; myocardial infarct; infarct size ... See more keywords