Toxic effects of triptolide on adrenal steroidogenesis in H295R cells and female rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22394
Abstract: Triptolide (TP), a major active ingredient of Tripterygium wilfordii, exerts potent immunosuppressive effects in the treatment of rheumatoid arthritis but is not widely used in clinical practice due to its multiorgan toxicity, particularly hepatotoxicity, nephrotoxicity,… read more here.
Keywords: triptolide adrenal; adrenal steroidogenesis; h295r; h295r cells ... See more keywords
The Adverse Effects of Triptolide on the Reproductive System of Caenorhabditis elegans: Oogenesis Impairment and Decreased Oocyte Quality
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18020464
Abstract: Previous studies have revealed that Triptolide damages female reproductive capacity, but the mechanism is unclear. In this study, we used Caenorhabditis elegans to investigate the effects of Triptolide on the germline and explore its possible… read more here.
Keywords: adverse effects; oocyte quality; effects triptolide; caenorhabditis elegans ... See more keywords
Prophylactic effects of triptolide on colon cancer development in azoxymethane/dextran sulfate sodiuminduced mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v16i11.13
Abstract: Purpose: To investigate effects of triptolide on colon cancer cell growth and its capacity to prevent tumor development in an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model of colon cancer. Methods: HCT116 cell viability and… read more here.
Keywords: triptolide colon; development azoxymethane; colon cancer; effects triptolide ... See more keywords