COVID-19: vaccines, efficacy and effects on variants
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Pulmonary Medicine"
DOI: 10.1097/mcp.0000000000000868
Abstract: Purpose of review We reviewed three leading strategies of vaccine development against coronavirus disease 2019 (COVID- 19): mRNA vaccines, adenoviral vector vaccines and recombinant nanoparticles. We also considered the emergence of severe acute respiratory syndrome… read more here.
Keywords: development; covid vaccines; covid; effects variants ... See more keywords
DeMAG predicts the effects of variants in clinically actionable genes by integrating structural and evolutionary epistatic features
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1101/2022.06.15.496230
Abstract: Interpretation of rare genetic variants remains challenging. Here, the authors develop a supervised variant effect predictor for use in clinically actionable genes which incorporates evolutionary and structural relationships between residues and has balanced specificity and… read more here.
Keywords: demag predicts; clinically actionable; predicts effects; disease genes ... See more keywords