Metabolic‐Efferocytosis Enabled Hydrogel Synergism Reprograms Immune Microenvironment for Promoting Diabetic Wound Repair
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202420079
Abstract: Diabetic wound healing remains a significant challenge, due to chronic inflammatory apoptotic cells accumulation. Herein, an immuno‐bioenergy regulated hydrogel (CCE) is reported, which converts apoptotic cells into cytokines that facilitate tissue repair. The CCE consisted… read more here.
Keywords: diabetic wound; repair; efferocytosis; citrate ... See more keywords
Macrophage‐Targeted Efferocytosis Therapy Promotes Diabetic Wound Healing via Cellular Level Debridement
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DOI: 10.1002/adfm.202503035
Abstract: Impaired efferocytosis in diabetic wounds contributes to apoptotic cell accumulation, chronic inflammation, and poor healing outcomes. In this study, a multi‐hierarchical hydrogel designed to facilitate cellular debridement and initiate a healing process in diabetic wounds… read more here.
Keywords: therapy; wound healing; macrophage targeted; efferocytosis ... See more keywords
Efferocytosis‐Inspired Biomimetic Nanoplatform for Targeted Acute Lung Injury Therapy
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DOI: 10.1002/adhm.202304304
Abstract: Acute lung injury (ALI) is a serious inflammatory disease that causes impairment of pulmonary function. Phenotypic modulation of macrophage in the lung using fibroblast growth factor 21 (FGF21) may be a potential strategy to alleviate… read more here.
Keywords: lung injury; fgf21; efferocytosis; acute lung ... See more keywords
In Situ Remodeling of Efferocytosis via Lesion‐Localized Microspheres to Reverse Cartilage Senescence
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DOI: 10.1002/advs.202400345
Abstract: Efferocytosis, an intrinsic regulatory mechanism to eliminate apoptotic cells, will be suppressed due to the delayed apoptosis process in aging‐related diseases, such as osteoarthritis (OA). In this study, cartilage lesion‐localized hydrogel microspheres are developed to… read more here.
Keywords: lesion localized; efferocytosis; cartilage; cartilage senescence ... See more keywords
Engineering Efferocytosis‐Mimicking Nanovesicles to Regulate Joint Anti‐Inflammation and Peripheral Immunosuppression for Rheumatoid Arthritis Therapy
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DOI: 10.1002/advs.202404198
Abstract: Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation of the synovial joints and the dysfunction of regulatory T cells (Tregs) in the peripheral blood. Therefore, an optimal treatment strategy should aim to… read more here.
Keywords: rheumatoid arthritis; mimicking nanovesicles; efferocytosis; efferocytosis mimicking ... See more keywords
Macrophage efferocytosis in health and disease
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3780
Abstract: Creating cellular homeostasis within a defined tissue typically relates to the processes of apoptosis and efferocytosis. A great example here is cell debris that must be removed to prevent unwanted inflammatory responses and then reduce… read more here.
Keywords: efferocytosis; macrophage efferocytosis; efferocytosis health; health disease ... See more keywords
The role of fat‐soluble vitamins in efferocytosis
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3972
Abstract: Cell death and the efficient removal of dead cells are two basic mechanisms that maintain homeostasis in multicellular organisms. efferocytosis, which includes four steps recruitment, recognition, binding and signaling, and engulfment. Effectively and quickly removes… read more here.
Keywords: effect; vitamins efferocytosis; fat soluble; role fat ... See more keywords
The cross‐talk between soluble “Find me” and “Keep out” signals as an initial step in regulating efferocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30770
Abstract: The rapid clearance of apoptotic cells (ACs), known as efferocytosis, prompts the inhibition of inflammatory responses and autoimmunity and maintains homeostatic cell turnover by controlling the release of intracellular contents. The fast clearance of ACs… read more here.
Keywords: find keep; step; keep signals; cross talk ... See more keywords
Involvement of phosphatidylserine receptors in the skeletal muscle regeneration: therapeutic implications
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13024
Abstract: Sarcopenia is a progressive loss of muscle mass and strength with a risk of adverse outcomes such as disability, poor quality of life, and death. Increasing evidence indicates that diminished ability of the muscle to… read more here.
Keywords: cell; efferocytosis; muscle; muscle regeneration ... See more keywords
Engineering Efferocytosis for Bone Regeneration
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DOI: 10.1002/mabi.202500094
Abstract: Bone is an incredibly robust tissue thanks to its high blood supply, rapid cell turnover, and continuous remodeling. A significant body of research investigates strategies to improve osteogenesis, angiogenesis, and immunomodulation for bone regeneration, facilitated… read more here.
Keywords: efferocytosis bone; bone regeneration; efferocytosis; bone ... See more keywords
Tyro3, Axl, Mertk receptor-mediated efferocytosis and immune regulation in the tumor environment.
Sign Up to like & getrecommendations! Published in 2021 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2021.02.002
Abstract: Three structurally related tyrosine receptor cell surface kinases, Tyro3, Axl, and Mertk (TAM) have been recognized to modulate immune function, tissue homeostasis, cardiovasculature, and cancer. The TAM receptor family appears to operate in adult mammals… read more here.
Keywords: immune; axl mertk; efferocytosis; tyro3 axl ... See more keywords