Macrophage efferocytosis in health and disease
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3780
Abstract: Creating cellular homeostasis within a defined tissue typically relates to the processes of apoptosis and efferocytosis. A great example here is cell debris that must be removed to prevent unwanted inflammatory responses and then reduce… read more here.
Keywords: efferocytosis; macrophage efferocytosis; efferocytosis health; health disease ... See more keywords
The cross‐talk between soluble “Find me” and “Keep out” signals as an initial step in regulating efferocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30770
Abstract: The rapid clearance of apoptotic cells (ACs), known as efferocytosis, prompts the inhibition of inflammatory responses and autoimmunity and maintains homeostatic cell turnover by controlling the release of intracellular contents. The fast clearance of ACs… read more here.
Keywords: find keep; step; keep signals; cross talk ... See more keywords
Involvement of phosphatidylserine receptors in the skeletal muscle regeneration: therapeutic implications
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13024
Abstract: Sarcopenia is a progressive loss of muscle mass and strength with a risk of adverse outcomes such as disability, poor quality of life, and death. Increasing evidence indicates that diminished ability of the muscle to… read more here.
Keywords: cell; efferocytosis; muscle; muscle regeneration ... See more keywords
Tyro3, Axl, Mertk receptor-mediated efferocytosis and immune regulation in the tumor environment.
Sign Up to like & getrecommendations! Published in 2021 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2021.02.002
Abstract: Three structurally related tyrosine receptor cell surface kinases, Tyro3, Axl, and Mertk (TAM) have been recognized to modulate immune function, tissue homeostasis, cardiovasculature, and cancer. The TAM receptor family appears to operate in adult mammals… read more here.
Keywords: immune; axl mertk; efferocytosis; tyro3 axl ... See more keywords
Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.04.018
Abstract: Nearly every tissue in the body undergoes routine turnover of cells as part of normal healthy living. The majority of these cells undergoing turnover die via apoptosis, and then are rapidly removed by phagocytes by… read more here.
Keywords: edge efferocytosis; interface homeostasis; efferocytosis interface; efferocytosis ... See more keywords
Effect of efferocytosis of apoptotic mesenchymal stem cells (MSCs) on C57BL/6 peritoneal macrophages function
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.09.052
Abstract: ABSTRACT Phagocytic clearance of apoptotic cells (Efferocytosis) could affect the polarization of macrophages and promote M2 anti‐inflammatory and regulatory phenotype and function. Here we tested the hypothesis that efferocytosis of apoptotic Adipose‐Derived Mesenchymal Stem Cells… read more here.
Keywords: efferocytosis apoptotic; efferocytosis; cells mscs; stem cells ... See more keywords
Nutrition: Start your day with a high-energy breakfast
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Cardiology"
DOI: 10.1038/nrcardio.2017.164
Abstract: Defective efferocytosis, the process of apoptotic cell clearance by macrophages, is a critical factor in the pathogenesis of atherosclerosis that leads to the accumulation of apoptotic cells and debris in atherosclerotic plaques. Uptake of multiple… read more here.
Keywords: nutrition start; efferocytosis; apoptotic cell; start day ... See more keywords
Stabilin-1-Mediated Efferocytosis Protects against Vascular Leakage in Sepsis: A Novel Therapeutic Approach?
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0038-1673688
Abstract: Sepsis is a complex clinical syndrome with high lethality characterized by systemic inflammation and organ failure.1 Although intensive research over the past decades has identified several mechanisms contributing to sepsis pathology, sepsis represents a major… read more here.
Keywords: sepsis; stab; efferocytosis; vascular leakage ... See more keywords
MO244CD47 BLOCKADE AMELIORATES AUTOIMMUNE VASCULITIS VIA THE EFFEROCYTOSIS OF NEUTROPHIL EXTRACELLULAR TRAPS*
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab104.002
Abstract: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by systemic necrotizing vasculitis in small vessels. The necrotic lesions consist of ANCA-mediated neutrophil extracellular traps (NETs) which represent a form of lytic cell death. The persistent… read more here.
Keywords: efferocytosis; control; anti cd47; cd47 ... See more keywords
Macrophage Efferocytosis in Cardiac Pathophysiology and Repair.
Sign Up to like & getrecommendations! Published in 2020 at "Shock"
DOI: 10.1097/shk.0000000000001625
Abstract: As an integral component of cardiac tissue, macrophages are critical for cardiac development, adult heart homeostasis, as well as cardiac healing. One fundamental function of macrophages involves the clearance of dying cells or debris, a… read more here.
Keywords: efferocytosis; pathophysiology repair; cardiac pathophysiology; macrophage efferocytosis ... See more keywords
Efferocytosis: molecular mechanisms and pathophysiological perspectives
Sign Up to like & getrecommendations! Published in 2019 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12206
Abstract: During the life of a human being, several tons of apoptotic cells and debris are produced. These apoptotic particles should be cleared quickly and accurately from the body, as they may lose their membrane integrity… read more here.
Keywords: efferocytosis molecular; efferocytosis; pathophysiological perspectives; molecular mechanisms ... See more keywords