Safety and Efficacy of Antithrombotic Strategies in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Network Meta-analysis of Randomized Controlled Trials.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2019.1880
Abstract: Importance The antithrombotic treatment of patients with atrial fibrillation (AF) and coronary artery disease, in particular with acute coronary syndrome (ACS) and/or percutaneous coronary intervention (PCI), poses a significant treatment dilemma in clinical practice. Objective… read more here.
Keywords: inhibitor; analysis; p2y12 inhibitor; safety ... See more keywords
Efficacy and Safety of Guselkumab, an Anti–interleukin 23 Monoclonal Antibody, for Palmoplantar Pustulosis: A Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2017.5937
Abstract: Importance Palmoplantar pustulosis (PPP) is a recalcitrant skin disease with no biologics currently approved for treatment. The involvement of interleukin 23 (IL-23) and cytokines of the type 17 helper T cell lineage in the pathogenesis… read more here.
Keywords: week; trial; safety; group ... See more keywords
Efficacy and Safety of Guselkumab in Japanese Patients With Palmoplantar Pustulosis: A Phase 3 Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2019.1394
Abstract: Importance Palmoplantar pustulosis (PPP) causes erythematous, scaly plaques with recurrent sterile pustules refractory to treatment and with few randomized clinical trials conducted. Evidence points to involvement of interleukin 23 in the pathogenesis of PPP. Objective… read more here.
Keywords: dermatology; safety; group; randomized clinical ... See more keywords
Efficacy and Safety of Upadacitinib vs Dupilumab in Adults With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2021.3023
Abstract: Importance Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease with an unmet need for treatments that provide rapid and high levels of skin clearance and itch improvement. Objective To assess the safety and… read more here.
Keywords: week; safety; efficacy; upadacitinib dupilumab ... See more keywords
Efficacy of Inhaled Ciclesonide for Outpatient Treatment of Adolescents and Adults With Symptomatic COVID-19: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2021.6759
Abstract: Importance Systemic corticosteroids are commonly used in treating severe COVID-19. However, the role of inhaled corticosteroids in the treatment of patients with mild to moderate disease is less clear. Objective To determine the efficacy of… read more here.
Keywords: clinical trial; trial; randomized clinical; efficacy ... See more keywords
Efficacy and Safety of a Protein-Based SARS-CoV-2 Vaccine
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.10302
Abstract: Key Points Question Do the protein-based SARS-CoV-2 vaccines (FINLAY-FR-2 and FINLAY-FR-1A) provide safe and effective protection against SARS-CoV-2? Findings In this randomized clinical trial including 23 959 individuals, vaccine efficacy for prevention of polymerase chain reaction… read more here.
Keywords: prevention; efficacy; sars cov; protein based ... See more keywords
Safety, Immunogenicity, and Efficacy of the NVX-CoV2373 COVID-19 Vaccine in Adolescents: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2023.9135
Abstract: Importance Greater than 20% of cases and 0.4% of deaths from COVID-19 occur in children. Following demonstration of the safety and efficacy of the adjuvanted, recombinant spike protein vaccine NVX-CoV2373 in adults, the PREVENT-19 trial… read more here.
Keywords: safety; trial; nvx cov2373; efficacy ... See more keywords
Efficacy of Dequalinium Chloride vs Metronidazole for the Treatment of Bacterial Vaginosis
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.8661
Abstract: Key Points Question Is the efficacy of dequalinium chloride comparable to that of oral metronidazole for the treatment of bacterial vaginosis? Findings In this randomized clinical trial of 147 premenopausal women with bacterial vaginosis, the… read more here.
Keywords: dequalinium; efficacy; bacterial vaginosis; metronidazole ... See more keywords
Characteristics of Clinical Trials Evaluating Biosimilars in the Treatment of Cancer: A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.7230
Abstract: Importance Biologics account for almost half of US drug spending but may be subject to competitive pricing pressures by US Food and Drug Administration-approved biosimilars. The extent of the preapproval clinical testing that is needed… read more here.
Keywords: clinical trials; reference drug; efficacy; drug ... See more keywords
Efficacy and Safety of Mydriatic Microdrops for Retinopathy of Prematurity Screening: The MyMiROPS Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2024.5462
Abstract: Importance Commercial mydriatics administered in preterm infants during retinopathy of prematurity (ROP) screening have been associated with various cardiorespiratory and gastrointestinal adverse events. Objective To examine whether microdrops of a combined mixture of 1.67% phenylephrine… read more here.
Keywords: retinopathy prematurity; adverse events; standard drops; trial ... See more keywords
Optimized low‐dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12797
Abstract: The current standard of care for colorectal cancer (CRC) is a combination of chemotherapeutics, often supplemented with targeted biological drugs. An urgent need exists for improved drug efficacy and minimized side effects, especially at late‐stage… read more here.
Keywords: optimized low; low dose; treatment; efficacy ... See more keywords