The superior efficacy of anti-PD-1/PD-L1 immunotherapy in KRAS-mutant non-small cell lung cancer that correlates with an inflammatory phenotype and increased immunogenicity.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.10.027
Abstract: Immune checkpoint inhibitors against PD-1/PD-L1 yield improved survival rates of KRAS-mutant NSCLC patients, who conferred a poor prognosis without effective targeted therapy until now. Yet, the underlying association between KRAS mutations and immune responses remains… read more here.
Keywords: anti immunotherapy; immunogenicity; kras mutant; efficacy anti ... See more keywords
Safety and Efficacy of Anti-Vascular Endothelial Growth Factor Therapies for Neovascular Age-Related Macular Degeneration: A Report by the American Academy of Ophthalmology.
Sign Up to like & getrecommendations! Published in 2019 at "Ophthalmology"
DOI: 10.1016/j.ophtha.2018.07.028
Abstract: PURPOSE To review the evidence on the safety and efficacy of anti-vascular endothelial growth factor (VEGF) therapies for the treatment of neovascular age-related macular degeneration (AMD). METHODS A literature search of the PubMed and Cochrane… read more here.
Keywords: safety efficacy; ophthalmology; evidence; efficacy ... See more keywords
Vaccination with dendritic cells pulsed ex vivo with gp100 peptide-decorated liposomes enhances the efficacy of anti PD-1 therapy in a mouse model of melanoma.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.06.055
Abstract: BACKGROUND Targeting antigens to dendritic cells (DCs) via nanoparticles is a powerful strategy which improves the efficacy of ex vivo antigen-pulsed DC vaccines. METHODS In this study, liposomes were first decorated with gp10025-33 self-antigen and… read more here.
Keywords: anti therapy; gp100; pulsed vivo; dendritic cells ... See more keywords
An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis
Sign Up to like & getrecommendations! Published in 2019 at "Psychological Medicine"
DOI: 10.1017/s0033291719001995
Abstract: Abstract Background Accumulating evidence shows that a propensity towards a pro-inflammatory status in the brain plays an important role in schizophrenia. Anti-inflammatory drugs might compensate this propensity. This study provides an update regarding the efficacy… read more here.
Keywords: meta analysis; efficacy; update efficacy; anti inflammatory ... See more keywords
(-)-4-O-(4-O-β-D-glucopyranosylcaffeoyl) quinic acid enhanced the efficacy of anti-PD-L1 against esophageal carcinoma through inhibiting PI3K pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2021.1990315
Abstract: PURPOSE Using antibodies to block the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway as an immunotherapy has achieved great success in the clinical treatment of various types of carcinoma. However, the efficacy… read more here.
Keywords: glucopyranosylcaffeoyl quinic; inhibiting pi3k; quinic acid; efficacy anti ... See more keywords
Exploration of the efficacy of anti‐immunoglobulin E monoclonal antibodies in the treatment of allergic asthma
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13613
Abstract: The present study aims to evaluate the efficacy of an anti‐immunoglobulin E monoclonal antibody (omalizumab) in the treatment of allergic asthma (AS). A total of 34 patients with moderate‐to‐severe bronchial asthma admitted to the Respiratory… read more here.
Keywords: efficacy anti; anti immunoglobulin; efficacy; immunoglobulin monoclonal ... See more keywords
Factors Influencing the Efficacy of Anti-PD-1 Therapy in Chinese Patients with Advanced Melanoma
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DOI: 10.1155/2019/6454989
Abstract: Purpose Anti-PD-1 antibody improves the survival of patients with advanced melanoma. However, the efficacy and safety of anti-programmed death protein 1 (PD-1) antibody have not been fully elucidated in Chinese melanoma patients, who show high… read more here.
Keywords: advanced melanoma; antibody; patients advanced; oncology ... See more keywords
Efficacy of anti-CD19 chimeric antigen receptor modified T(CAR-T) cell therapy in Chinese patients with relapsed/refractory acute lymphocytic leukemia in a multicenter trial.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.7028
Abstract: 7028Background: r/r B-ALL was reported as the most-threatening disease because of the low disease free survival even treatment with allogeneic hematopoietic stem cell transplantation. For overcomin... read more here.
Keywords: cd19 chimeric; antigen receptor; anti cd19; cell ... See more keywords
Immunomodulatory effects of regorafenib: Enhancing the efficacy of anti-PD-1/PD-L1 therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.992611
Abstract: Anti-PD-1/PD-L1 therapy has shown significant benefits in the treatment of a variety of malignancies. However, not all cancer patients can benefit from this strategy due to drug resistance. Therefore, there is an urgent need for… read more here.
Keywords: effects regorafenib; efficacy anti; anti therapy; therapy ... See more keywords
Efficacy of Anti-seizure Medications, Quinidine, and Ketogenic Diet Therapy for KCNT1-Related Epilepsy and Genotype-Efficacy Correlation Analysis
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DOI: 10.3389/fneur.2021.834971
Abstract: Aim To evaluate the efficacy of anti-seizure medications (ASMs), quinidine, and ketogenic diet therapy (KDT) for KCNT1-related epilepsy and to explore genotype-efficacy correlations. Methods We collected the data for KCNT1-related epilepsy cases from our hospital's… read more here.
Keywords: genotype; related epilepsy; efficacy; kcnt1 related ... See more keywords
Biomarkers of Prognosis and Efficacy of Anti-angiogenic Therapy in Metastatic Clear Cell Renal Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.01400
Abstract: In the last decades, the prognosis of metastatic renal cell carcinoma (mRCC) has remarkably improved following the advent of the “targeted therapy” era. The expanding knowledge on the prominent role played by angiogenesis in RCC… read more here.
Keywords: biomarkers prognosis; prognosis efficacy; therapy; anti angiogenic ... See more keywords