Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies
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DOI: 10.3324/haematol.2018.204701
Abstract: BH3 mimetics are novel targeted drugs with remarkable specificity, potency and enormous potential to improve cancer therapy. However, acquired resistance is an emerging problem. We report the rapid development of resistance in chronic lymphocytic leukemia… read more here.
Keywords: efficacy bh3; intermediary metabolism; mimetic therapy; resistance ... See more keywords