Silencing of SIRPα enhances the antitumor efficacy of CAR-M in solid tumors
Sign Up to like & getrecommendations! Published in 2024 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-024-01220-3
Abstract: The potential of macrophage-mediated phagocytosis as a cancer treatment is promising. Blocking the CD47–SIRPα interaction with a CD47-specific antibody significantly enhances macrophage phagocytosis. However, concerns regarding their toxicity to nontumor cells remain substantial. Here, we… read more here.
Keywords: antitumor efficacy; efficacy car; solid tumors; car ... See more keywords
DIPG-11. PRECLINICAL EFFICACY OF B7-H3 CAR T CELLS IN COMBINATION WITH ONC206
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae064.064
Abstract: Abstract Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric tumor of the pons affecting over 300 children in the U.S. each year. Chimeric antigen receptor (CAR) T cells are a targeted immunotherapy with remarkable… read more here.
Keywords: car; efficacy car; dipg preclinical; car cells ... See more keywords