High baseline tumor burden‐associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2‐STAT3‐PD‐L1 pathway
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DOI: 10.1002/cac2.12420
Abstract: Several clinical studies have uncovered a negative correlation between baseline tumor burden and the efficacy of immune checkpoint inhibitor (ICI) treatment. This study aimed to uncover the specific mechanisms underlying the difference in sensitivity to… read more here.
Keywords: immune checkpoint; baseline tumor; tumor burden; efficacy immune ... See more keywords
The correlation between the influencing factors and efficacy of immune checkpoint inhibitor therapy: an umbrella meta-analysis of randomized controlled trials
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DOI: 10.1080/07853890.2023.2215543
Abstract: Abstract Objective We performed an umbrella meta-analysis to explore the factors that influence the efficacy of immune checkpoint inhibitor (ICI) therapy. Materials and methods We systematically searched three databases (PubMed, Web of Science and Embase)… read more here.
Keywords: meta analysis; immune checkpoint; therapy; umbrella meta ... See more keywords
The intestinal microbiota determines the clinical efficacy of immune checkpoint blockers targeting PD-1/PD-L1
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DOI: 10.1080/2162402x.2018.1434468
Abstract: ABSTRACT Cancer immunotherapists have been searching for biomarkers predicting patient responses to PD-1/PD-L1 blockade in neoplastic cells as well as in the immune system. Now, accumulating evidence indicates that the composition of the intestinal microflora… read more here.
Keywords: immune checkpoint; microbiota determines; clinical efficacy; intestinal microbiota ... See more keywords
Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies
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DOI: 10.1080/2162402x.2019.1673635
Abstract: ABSTRACT Glucocorticoids mediate potent anti-inflammatory and immunosuppressive effects. A chronic elevation of the endogenous glucocorticoid tonus subsequent to mental stress, as well as continuous treatment with exogenous glucocorticoids, activate an immunosuppressive transcription factor, TSC22D3, in… read more here.
Keywords: abolish efficacy; exogenous glucocorticoids; glucocorticoids abolish; cancer ... See more keywords
Association of thyroid transcription factor‐1 with the efficacy of immune‐checkpoint inhibitors in patients with advanced lung adenocarcinoma
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DOI: 10.1111/1759-7714.14560
Abstract: We aimed to identify the relationship between thyroid transcription factor‐1 (TTF‐1) expression of lung adenocarcinoma and the efficacy of immune‐checkpoint inhibitor (ICI) therapy. read more here.
Keywords: thyroid transcription; lung adenocarcinoma; immune checkpoint; transcription factor ... See more keywords
Cumulative antibiotic use and efficacy of immune checkpoint inhibitors in patients with advanced cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.3010
Abstract: 3010Background: Efficacy of immune checkpoint inhibitors (CKIs) for treatment of cancer may be affected by the use of antibiotics (ABX). The gut microbiome is involved in immunotherapy responses th... read more here.
Keywords: immune checkpoint; efficacy immune; checkpoint inhibitors; cancer ... See more keywords
Efficacy of immune-checkpoint inhibitors (ICI) in non-small cell lung cancer (NSCLC) patients harboring activating molecular alterations.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.5_suppl.172
Abstract: 172Background: Two revolutions recently occur in the treatment of advanced NSCLC: the development of targeted therapies and of ICI). Both strategies have been shown to outperform chemotherapy. Patients with molecular alterations are usually considered as… read more here.
Keywords: nsclc patients; molecular alterations; activating molecular; efficacy immune ... See more keywords
Efficacy of immune checkpoint inhibitors (ICI) and genomic characterization of sarcomatoid and/or rhabdoid (S/R) metastatic renal cell carcinoma (mRCC).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.4514
Abstract: 4514 Background: S/R mRCC are poorly characterized rapidly progressing tumors associated with poor prognosis. Although conventional therapies are less effective for these tumors, emerging data suggests that ICIs may be especially effective. Our aim was… read more here.
Keywords: pts treated; non ici; mrcc; cell ... See more keywords
What impact do the proton pump inhibitors have on the efficacy of immune check point inhibitors in metastatic malignant melanoma?
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DOI: 10.1200/jco.2019.37.15_suppl.e21040
Abstract: e21040 Background: Acidic microenvironment facilitates the proliferation, progression, and metastasis of the tumors. Mouse models have shown that the proton pump inhibitors (PPI) cause neutralization of the acidic tumor microenvironment (TME) and inhibit the tumor… read more here.
Keywords: proton pump; impact; cohort; pump inhibitors ... See more keywords
Impact of antibiotic exposure on the efficacy of immune checkpoint blockade in MSI-H metastatic CRC.
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DOI: 10.1200/jco.2020.38.4_suppl.161
Abstract: 161Background: Immunotherapy has improved outcomes for many patients (pts) with advanced cancers found to be microsatellite instability high (MSI-H). However, not all MSI-H pts exhibit the same eff... read more here.
Keywords: immune checkpoint; efficacy immune; msi; exposure efficacy ... See more keywords
Long-term efficacy of immune checkpoint inhibitors in advanced NSCLC: challenges and opportunities—a commentary of the 3-year follow-up of the KEYNOTE-001 trial
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DOI: 10.21037/tcr.2019.06.24
Abstract: Treatment of advanced non-small cell lung cancer (NSCLC) has evolved considerably over the past two decades, with improved survival outcomes in a significant proportion of patients due to the development of new effective systemic therapies.… read more here.
Keywords: immune checkpoint; term efficacy; inhibitors advanced; checkpoint inhibitors ... See more keywords