Efficacy of a PARP inhibitor combination
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Urology"
DOI: 10.1038/s41585-018-0048-3
Abstract: A randomized phase II trial reports the clinical efficacy of poly(ADPribose) polymerase (PARP) inhibitor olaparib combined with abiraterone in metastatic castrationresistant prostate cancer. At a cutoff date in September 2017, median radiographic progressionfree survival was… read more here.
Keywords: inhibitor combination; parp inhibitor; efficacy parp; efficacy ... See more keywords
Evaluation of the Efficacy of PARP Inhibitors in Metastatic Castration-Resistant Prostate Cancer: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.777663
Abstract: Background: Poly(ADP-ribose) polymerase (PARP) inhibitors have breakthrough designations for metastatic castration-resistant prostate cancer (mCRPC). We performed a meta-analysis of current clinical trials to evaluate the efficacy of PARP inhibitors in mCRPC patients based on their… read more here.
Keywords: castration resistant; efficacy parp; hrd; metastatic castration ... See more keywords