Safety, efficacy, and pharmacokinetics of SH‐1028 in EGFR T790M‐positive advanced non–small cell lung cancer patients: A dose‐escalation phase 1 study
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DOI: 10.1002/cncr.34697
Abstract: SH‐1028 is a new third‐generation EGFR tyrosine kinase inhibitors (TKI) to benefit patients with EGFR T790M‐mutated NSCLC. Here, the authors report its clinical safety, preliminary efficacy, and pharmacokinetic (PK) profile for the first time. read more here.
Keywords: safety; safety efficacy; cancer; egfr t790m ... See more keywords
Injectable eprinomectin for cattle: Tick efficacy and pharmacokinetics.
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DOI: 10.1111/jvp.12840
Abstract: The aims of the present study were to evaluate the pharmacokinetic profile and efficacy of eprinomectin (EPM) against Rhipicephalus microplus in cattle of a new injectable form of EPM (Voss Performa®). The product was administered… read more here.
Keywords: cattle tick; tick efficacy; injectable eprinomectin; efficacy pharmacokinetics ... See more keywords
Preliminary safety, efficacy and pharmacokinetics (PK) results of KN026, a HER2 bispecific antibody in patients (pts) with HER2-positive metastatic breast cancer.
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DOI: 10.1200/jco.2020.38.15_suppl.1041
Abstract: 1041Background: KN026 is a novel bispecific antibody that simultaneously binds to two distinct HER2 epitopes, the same domains as trastuzumab (ECD4) and pertuzumab (ECD2). It blocks ligand-dependen... read more here.
Keywords: efficacy pharmacokinetics; safety efficacy; antibody; pharmacokinetics results ... See more keywords
In vivo Efficacy and Pharmacokinetics of Optimized Apidaecin Analogs
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DOI: 10.3389/fchem.2017.00015
Abstract: Proline-rich antimicrobial peptides (PrAMPs) represent promising alternative therapeutic options for the treatment of multidrug-resistant bacterial infections. PrAMPs are predominantly active against Gram-negative bacteria by inhibiting protein expression via at least two different modes of action,… read more here.
Keywords: efficacy pharmacokinetics; api88 api137; infection; efficacy ... See more keywords