Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1268
Abstract: Abstract Genome editing with the CRISPR–Cas9 system has enabled unprecedented efficacy for reverse genetics and gene correction approaches. While off-target effects have been successfully tackled, the effort to eliminate variability in sgRNA efficacies—which affect experimental… read more here.
Keywords: crispr cas9; efficacy; sgrna efficacy; efficacy prediction ... See more keywords
EFFICACY PREDICTION SCORE OF HYPERTENSION DIGITAL THERAPEUTICS: THE BEHAVIORAL MODIFICATION INDEX (B-INDEX) STUDY
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DOI: 10.1097/01.hjh.0001117088.81485.5e
Abstract: OBJECTIVE Assess the effects of a workplace multicomponent lifestyle intervention compared to active breaks and health education on cardiovascular risk factors, subjective well-being, and quality of life. METHODS A total of 266 industry workers were… read more here.
Keywords: efficacy prediction; group; prediction score; index ... See more keywords
Visualization of dose parameters and efficacy prediction in vascular-targeted photodynamic therapy based on a hyperspectral imaging system
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DOI: 10.1364/boe.577655
Abstract: Vascular-targeted photodynamic therapy (V-PDT) is a promising treatment for benign vascular proliferative disorders. However, its efficacy largely depends on clinicians’ experience due to the lack of reliable methods for efficacy prediction. To provide an objective… read more here.
Keywords: efficacy prediction; dose parameters; prediction; hyperspectral imaging ... See more keywords
Expressions of IFN-γ and IL-4 before and after Treatment of Lupus Nephritis with Traditional Chinese Medicine Combined with Cyclophosphamide and Their Values for Efficacy Prediction and Evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Iranian Journal of Public Health"
DOI: 10.18502/ijph.v49i5.3205
Abstract: Background: To explore IFN-γ (interferon-γ) and IL-4 (interleukin-4) expressions before and after the treatment of LN (lupus nephritis) and their values for efficacy prediction and evaluation. Methods: Altogether 107 patients with LN treated in the… read more here.
Keywords: efficacy prediction; medicine; lupus; treatment ... See more keywords
Pharmacokinetics, Pharmacodynamic Efficacy Prediction Indexes and Monte Carlo Simulations of Enrofloxacin Hydrochloride Against Bacterial Strains That Induce Common Clinical Diseases in Broiler Chickens
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2020.606872
Abstract: Pharmacokinetic parameters and efficacy prediction indexes (Cmax/MIC90 and AUC0−24/MIC90) of an enrofloxacin hydrochloride (ENR-HCl) veterinary product soluble in water were determined in healthy broiler chickens of both sexes after a single oral dose of ENR-HCl… read more here.
Keywords: prediction indexes; enr hcl; monte carlo; broiler chickens ... See more keywords