Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1268
Abstract: Abstract Genome editing with the CRISPR–Cas9 system has enabled unprecedented efficacy for reverse genetics and gene correction approaches. While off-target effects have been successfully tackled, the effort to eliminate variability in sgRNA efficacies—which affect experimental… read more here.
Keywords: crispr cas9; efficacy; sgrna efficacy; efficacy prediction ... See more keywords
Expressions of IFN-γ and IL-4 before and after Treatment of Lupus Nephritis with Traditional Chinese Medicine Combined with Cyclophosphamide and Their Values for Efficacy Prediction and Evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Iranian Journal of Public Health"
DOI: 10.18502/ijph.v49i5.3205
Abstract: Background: To explore IFN-γ (interferon-γ) and IL-4 (interleukin-4) expressions before and after the treatment of LN (lupus nephritis) and their values for efficacy prediction and evaluation. Methods: Altogether 107 patients with LN treated in the… read more here.
Keywords: efficacy prediction; medicine; lupus; treatment ... See more keywords
Pharmacokinetics, Pharmacodynamic Efficacy Prediction Indexes and Monte Carlo Simulations of Enrofloxacin Hydrochloride Against Bacterial Strains That Induce Common Clinical Diseases in Broiler Chickens
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2020.606872
Abstract: Pharmacokinetic parameters and efficacy prediction indexes (Cmax/MIC90 and AUC0−24/MIC90) of an enrofloxacin hydrochloride (ENR-HCl) veterinary product soluble in water were determined in healthy broiler chickens of both sexes after a single oral dose of ENR-HCl… read more here.
Keywords: prediction indexes; enr hcl; monte carlo; broiler chickens ... See more keywords