Efficacy and Safety of Upadacitinib in Patients With Moderate to Severe Atopic Dermatitis
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2022.0029
Abstract: This analysis of 2 randomized clinical trials evaluates long-term (52 weeks) efficacy and safety of upadacitinib treatment in patients with atopic dermatitis. read more here.
Keywords: safety upadacitinib; upadacitinib patients; efficacy safety; atopic dermatitis ... See more keywords
Efficacy and Safety of Dupilumab in Patients With Erythrodermic Atopic Dermatitis
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DOI: 10.1001/jamadermatol.2022.6192
Abstract: This post hoc analysis of 6 randomized, double-blind, placebo-controlled trials assesses the efficacy and safety of dupilumab in patients with erythrodermic atopic dermatitis. read more here.
Keywords: patients erythrodermic; erythrodermic atopic; dupilumab patients; efficacy safety ... See more keywords
Efficacy and Safety of Vamorolone in Duchenne Muscular Dystrophy
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DOI: 10.1001/jamanetworkopen.2021.44178
Abstract: This nonrandomized controlled trial examines efficacy of vamorolone treatment for Duchenne muscular dystrophy among boys compared with glucocorticoid treatment. read more here.
Keywords: efficacy safety; duchenne muscular; safety vamorolone; muscular dystrophy ... See more keywords
Efficacy and Safety of Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron for Glycemic Control Among Patients With Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.14493
Abstract: Key Points Question Among adults with type 2 diabetes (T2D), what is the efficacy, safety, and tolerability of the novel, orally administered, small molecule glucagon-like peptide 1 receptor agonist danuglipron? Findings In this phase 2… read more here.
Keywords: efficacy safety; like peptide; peptide receptor; glucagon like ... See more keywords
Efficacy and Safety of Rivaroxaban for Postoperative Thromboprophylaxis in Patients After Bariatric Surgery
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DOI: 10.1001/jamanetworkopen.2023.15241
Abstract: Key Points Question Is thromboprophylaxis with 10 mg of rivaroxaban for 7 and 28 days after bariatric surgery efficacious and safe? Findings In this randomized clinical trial, 272 patients undergoing bariatric surgery were assigned to… read more here.
Keywords: surgery; rivaroxaban postoperative; postoperative thromboprophylaxis; efficacy safety ... See more keywords
Efficacy and Safety of Esketamine for Supplemental Analgesia During Elective Cesarean Delivery
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DOI: 10.1001/jamanetworkopen.2023.9321
Abstract: Key Points Question Is intravenous esketamine safe and effective before childbirth during cesarean delivery with epidural anesthesia? Findings In this multicenter, double-blind, randomized clinical trial of 600 women undergoing cesarean delivery with epidural anesthesia, a… read more here.
Keywords: supplemental analgesia; cesarean delivery; safety esketamine; efficacy safety ... See more keywords
Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2022.0829
Abstract: This randomized clinical trial examines the change from baseline in drop seizure frequency, response rates, and improvement on the Clinical Global Impression scale among patients with Lennox-Gastaut syndrome. read more here.
Keywords: lennox gastaut; safety fenfluramine; fenfluramine treatment; treatment seizures ... See more keywords
Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis.
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DOI: 10.1001/jamapediatrics.2022.5648
Abstract: Importance Despite advances in the understanding of dietary therapies in children with drug-resistant epilepsy, no quantitative comparison exists between different dietary interventions. Objective To evaluate the comparative efficacy and safety of various dietary therapies in… read more here.
Keywords: dietary therapies; drug resistant; efficacy safety; epilepsy ... See more keywords
Assessment of Efficacy and Safety of mRNA COVID-19 Vaccines in Children Aged 5 to 11 Years: A Systematic Review and Meta-analysis.
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DOI: 10.1001/jamapediatrics.2022.6243
Abstract: Importance Evidence of the efficacy and safety of messenger RNA (mRNA) COVID-19 vaccines in children aged 5 to 11 years has been emerging. Collecting these data will inform clinicians, families, and policy makers. Objective To… read more here.
Keywords: safety; children aged; aged years; mrna covid ... See more keywords
Efficacy and safety of half‐dose desmopressin for bleeding prophylaxis in bleeding disorder patients undergoing predominantly low to moderate risk invasive procedures
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DOI: 10.1002/ajh.25928
Abstract: of disease in pyruvate kinase deficiency and their management. Haematologica. 2020:haematol.2019.240846. https://doi.org/10.3324/ haematol.2019.240846. 5. Necheles TF, Finkel HE, Sheehan RG, Allen DM. Red cell pyruvate kinase deficiency. The effect of splenectomy. Arch Intern Med. 1966;… read more here.
Keywords: pyruvate kinase; half dose; efficacy safety; desmopressin bleeding ... See more keywords
Impact of Philadelphia chromosome‐like alterations on efficacy and safety of blinatumomab in adults with relapsed/refractory acute lymphoblastic leukemia: A post hoc analysis from the phase 3 TOWER study
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26281
Abstract: Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subgroup of precursor B-cell (BCP) ALL. In the phase 3 TOWER trial (NCT02013167), blinatumomab demonstrated superior overall survival (OS) than standard of care chemotherapy (SOC)… read more here.
Keywords: efficacy safety; safety blinatumomab; blinatumomab; patients like ... See more keywords