Synthesis of rigidified shikimic acid derivatives by ring-closing metathesis to imprint inhibitor efficacy against shikimate kinase enzyme
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DOI: 10.1039/c9qo00562e
Abstract: The rigidification of the high-energy conformation of shikimic acid was used to enhance inhibitor efficacy against shikimate kinase enzyme, an attractive target for antibiotic drug discovery. read more here.
Keywords: shikimic acid; inhibitor efficacy; kinase enzyme; efficacy shikimate ... See more keywords