Herpes virus entry mediator costimulation signaling enhances CAR-T cell efficacy against solid tumors through metabolic reprogramming.
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DOI: 10.1158/2326-6066.cir-22-0531
Abstract: Costimulatory domains (CSD) of 4-1BB and CD28 are most widely used in chimeric antigen receptor-engineered T (CAR-T) cells. These CAR-T cells have shown encouraging efficacy in the treatment of hematologic malignancies but have limited efficacy… read more here.
Keywords: herpes virus; efficacy solid; car; efficacy ... See more keywords