Identification, Efficacy, and Stability Evaluation of Succinimide Modification With a High Abundance in the Framework Region of Golimumab
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DOI: 10.3389/fchem.2022.826923
Abstract: Succinimide (Asu) is the intermediate for asparagine deamidation in therapeutic proteins, and it can be readily hydrolyzed to form aspartate and iso-aspartate residues. Moreover, Asu plays an important role in the protein degradation pathways, asparagine… read more here.
Keywords: modification; efficacy stability; efficacy; high abundance ... See more keywords