In vivo efficacy studies of novel quinazoline derivatives as irreversible dual EGFR/HER2 inhibitors, in lung cancer xenografts (NCI-H1975) mice models.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103790
Abstract: Lung cancer is the most common cancer and leading cause of cancer-related deaths worldwide. The first-generation reversible, ATP-competitive inhibitors gefetinib and elotinib showed good clinical responses in lung adenocarcinoma tumors (NSCLC). But almost all patients… read more here.
Keywords: efficacy studies; nci h1975; generation; lung cancer ... See more keywords
Diphenyl triazine hybrids inhibit α-synuclein fibrillogenesis: Design, synthesis and in vitro efficacy studies.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112705
Abstract: Aggregation of α-synuclein (α-syn) is one of the central hypotheses for Parkinson's disease (PD), therefore, its inhibition and disaggregation is an optimistic approach for the treatment of PD. Here, we report design, synthesis and in-vitro… read more here.
Keywords: design synthesis; efficacy studies; diphenyl triazine; vitro efficacy ... See more keywords
Blood transfusion in the care of patients with visceral leishmaniasis: a review of practices in therapeutic efficacy studies
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DOI: 10.1093/trstmh/trae018
Abstract: Abstract Blood transfusion remains an important aspect of patient management in visceral leishmaniasis (VL). However, transfusion triggers considered are poorly understood. This review summarises the transfusion practices adopted in VL efficacy studies using the Infectious… read more here.
Keywords: visceral leishmaniasis; review; blood transfusion; efficacy studies ... See more keywords
Preclinical Immunogenicity and Efficacy Studies for Therapeutic Vaccines for Human Papillomavirus-Type-16-Associated Cancer
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DOI: 10.3390/vaccines12060616
Abstract: The objective of this study was to conduct preclinical immunogenicity and efficacy studies with several therapeutic vaccines for human papillomavirus (HPV)-16-associated cancers expressing the early antigens E5, E6, and E7 with or without E2. The… read more here.
Keywords: immunogenicity efficacy; therapeutic vaccines; efficacy studies; preclinical immunogenicity ... See more keywords